1型糖尿病诱发肌少症的研究进展

doi:10.16352/j.issn.1001-6325.2024.08.1189

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (8): 1189-1193.doi: 10.16352/j.issn.1001-6325.2024.08.1189

1型糖尿病诱发肌少症的研究进展

彭晴怡, 许岭翎^*

中国医学科学院北京协和医学院北京协和医院内分泌科,北京 100730

收稿日期:2023-10-08 修回日期:2024-03-29 出版日期:2024-08-05 发布日期:2024-07-24
通讯作者: ^*llxwsh@163.com
基金资助:
中央高水平医院临床科研业务费(2022-PUMCH-B-015)

Research progress on the type 1 diabetes induced sarcopenia

PENG Qingyi, XU Lingling^*

Department of Endocrinology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, China

Received:2023-10-08 Revised:2024-03-29 Online:2024-08-05 Published:2024-07-24
Contact: ^*llxwsh@163.com

摘要/Abstract

摘要： 1型糖尿病的肌少症患病率明显高于2型糖尿病及非糖尿病患者,尽早对1型糖尿病患者进行肌少症的筛查、诊断和干预治疗对于提高这些患者的生活质量具有重大意义。1型糖尿病患者肌少症的发生可能与胰岛素样生长因子-1减少、炎性因子激活、线粒体功能障碍、晚期糖基化终末产物蓄积等导致骨骼肌功能下降密切相关。目前,1型糖尿病诱发肌少症的发生发展机制并不完全明确,相关新药治疗缺乏数据支持,进一步的深入研究可能给1型糖尿病患者防治肌少症提供新的方向。

关键词: 1型糖尿病, 肌少症, 流行病学, 发病机制, 治疗

Abstract: The prevalence of sarcopenia in type 1 diabetes is higher than that in type 2 diabetes and non-diabetes patients. Screening, diagnosis and intervention of sarcopenia in type 1 diabetes patients as early as possible is of great significance for improving the life quality of these patients. The occurrence of sarcopenia in type 1 diabetes mellitus may be closely related to the decline of skeletal muscle function caused by the decrease of insulin-like growth factor-1, activation of inflammatory factors, mitochondrial dysfunction, and accumulation of advanced glycation end-products. At present, the mechanism of the occurrence and development of sarcopenia induced by type 1 diabetes is not completely clear, and the relevant new drug treatment lacks data support. Further in-depth research may bring a new direction for the prevention and treatment of sarcopenia in type 1 diabetes patients.

Key words: type 1 diabetes mellitus, sarcopenia, epidemiological, pathogenesis, treatment

中图分类号:

R587.1

彭晴怡, 许岭翎. 1型糖尿病诱发肌少症的研究进展[J]. 基础医学与临床, 2024, 44(8): 1189-1193.

PENG Qingyi, XU Lingling. Research progress on the type 1 diabetes induced sarcopenia[J]. Basic & Clinical Medicine, 2024, 44(8): 1189-1193.

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1型糖尿病诱发肌少症的研究进展

Research progress on the type 1 diabetes induced sarcopenia

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