基础医学与临床 ›› 2024, Vol. 44 ›› Issue (6): 882-886.doi: 10.16352/j.issn.1001-6325.2024.06.0882

• 短篇综述 • 上一篇    下一篇

代谢重编程在特发性肺纤维化发病中的作用

段然1#, 李青原1#, 冯同2*   

  1. 1.成都医学院第一附属医院, 四川 成都 610500;
    2.南方医科大学 第二临床医学院,广东 广州 510515
  • 收稿日期:2023-11-09 修回日期:2024-01-23 出版日期:2024-06-05 发布日期:2024-05-24
  • 通讯作者: *543051181@qq.com
  • 作者简介:#对本文有相同贡献
  • 基金资助:
    国家临床重点专科建设培育科室专项(CYFY2018GLPHX01)

Metabolic reprogramming in idiopathic pulmonary fibrosis

DUAN Ran1#, LI Qingyuan1#, FENG Tong2*   

  1. 1. the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500;
    2. the Second Clinical Medical College, Southern Medical University, Guangzhou 510515,China
  • Received:2023-11-09 Revised:2024-01-23 Online:2024-06-05 Published:2024-05-24
  • Contact: *543051181@qq.com

摘要: 肺纤维化是由肺泡上皮反复受损,导致异常的上皮-成纤维细胞转化和肌成纤维细胞产生,进而导致细胞外基质大量积累和间质重塑引起的。与大多数肿瘤细胞类似,肺纤维化过程中也发生了代谢重编程,包括糖、脂、氨基酸代谢等改变,具体表现为糖酵解的上调、脂肪酸氧化减弱而合成增强、谷氨酰胺分解增加。糖酵解为纤维化形成过程中巨噬细胞、成纤维细胞等的大量增殖提供快速和高效的能量供应,满足其能量需求。活化后的成纤维细胞氨基酸代谢重编程不仅促进了胶原的合成, 也在羟脯氨酸合成过程中通过形成ROS加剧了肌成纤维细胞活化进程。

关键词: 特发性肺纤维化, 代谢重编程, 糖酵解, 靶向治疗

Abstract: Pulmonary fibrosis is caused by repeated damage to the pulmonary alveolar epithelium, leading to abnormal epithelial-mesenchymal transition and myofibroblast production, resulting in the accumulation of extra cellular matrix and remodeling of the interstitium. Analogous to many tumor cells, pulmonary fibrosis involves metabolic reprogramming, encompassing alterations in carbohydrate, lipid, and amino acid metabolism. Notably, this reprogramming is marked by enhanced glycolysis, diminished fatty acid oxidation paired with augmented synthesis, and increased degradation of glutamine. Glycolysis efficiently and rapidly fulfills the energy requirements for the proliferation of macrophages and fibroblasts during fibrotic development. Additionally, the reprogramming of amino acid metabolism in activated fibroblasts not only facilitates collagen synthesis but also intensifies myofibroblast activation by generating reactive oxygen species (ROS) during the production of hydroxyproline.

Key words: idiopathic pulmonary fibrosis, metabolic reprogramming, glycolysis, targeted therapy

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