星形胶质细胞吞噬作用在阿尔茨海默病中的研究进展

doi:10.16352/j.issn.1001-6325.2024.08.1180

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (8): 1180-1184.doi: 10.16352/j.issn.1001-6325.2024.08.1180

星形胶质细胞吞噬作用在阿尔茨海默病中的研究进展

秦晓莉^1,2,3, 赵琳娜^1,2,4, 付榕^1,2,3, 郭玉莹^1,2,4, 徐士欣^1,2,4*

1.天津中医药大学第一附属医院,天津 300193;
2.国家中医针灸临床医学研究中心,天津 300193;
3.天津中医药大学研究生院,天津 301617;
4.中医方证转化研究重点实验室,天津 300193

收稿日期:2023-11-17 修回日期:2024-01-26 出版日期:2024-08-05 发布日期:2024-07-24
通讯作者: ^*xushixintj@163.com
基金资助:
天津市教委科研计划项目(2021KJ146)

Research progress of astrocyte phagocytosis in Alzheimer′s disease

QIN Xiaoli^1,2,3, ZHAO Linna^1,2,4, FU Rong^1,2,3, GUO Yuying^1,2,4, XU Shixin^1,2,4*

1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193;
2. National Acupuncture and Moxibustion Clinical Medical Research Center of Traditional Chinese Medicine, Tianjin 300193;
3. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617;
4. Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin 300193, China

Received:2023-11-17 Revised:2024-01-26 Online:2024-08-05 Published:2024-07-24
Contact: ^*xushixintj@163.com

摘要/Abstract

摘要： 星形胶质细胞在阿尔茨海默病中被大量激活,吞噬受损的突触、Aβ蛋白、Tau蛋白、凋亡细胞等底物。然而,这些底物难以降解,并随着疾病发展逐渐积累,损害星形胶质细胞的吞噬能力。在吞噬过程中,星形胶质细胞通过多种吞噬受体识别不同的底物,并借助降解酶和溶酶体途径对底物进行部分降解。星形胶质细胞中积累的Aβ和Tau蛋白造成星形胶质细胞免疫和代谢紊乱,而Aβ毒性也在吞噬后发生改变。此外,星型胶质细胞与小胶质细胞形成互补模式,并通过相互作用协同完成吞噬。调控星形胶质细胞吞噬和降解途径可能成为新的阿尔茨海默病治疗靶点。

关键词: 星形胶质细胞, 吞噬作用, 阿尔茨海默病

Abstract: Astrocytes are heavily activated in Alzheimer′s disease, engulfing damaged synapses, Aβ proteins, Tau proteins, apoptotic cells and other substrates. However, these substrates are difficult to degrade, accumulate as the disease progresses, and impair the phagocytosis of astrocytes. During phagocytosis, astrocytes recognize different substrates through a variety of phagocytosis receptors and partially degrade the substrates through degrading enzymes and lysosomal pathways. The accumulation of Aβ and Tau proteins in astrocytes caused astrocyte immune and metabolic disorders, and Aβ toxicity changed after phagocytosis. In addition, astrocytes and microglia form a complementary pattern and cooperate to complete phagocytosis through interaction. Regulating the pathway of astrocyte phagocytosis and degradation is believed to be a potential novo therapeutic for clinical treatment of Alzheimer′s disease.

Key words: astrocytes, phagocytosis, Alzheimer′s disease

中图分类号:

R749.16

秦晓莉, 赵琳娜, 付榕, 郭玉莹, 徐士欣. 星形胶质细胞吞噬作用在阿尔茨海默病中的研究进展[J]. 基础医学与临床, 2024, 44(8): 1180-1184.

QIN Xiaoli, ZHAO Linna, FU Rong, GUO Yuying, XU Shixin. Research progress of astrocyte phagocytosis in Alzheimer′s disease[J]. Basic & Clinical Medicine, 2024, 44(8): 1180-1184.

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星形胶质细胞吞噬作用在阿尔茨海默病中的研究进展

Research progress of astrocyte phagocytosis in Alzheimer′s disease

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