星形胶质细胞在中枢神经系统炎性疾病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.04.0665

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (4): 665-668.doi: 10.16352/j.issn.1001-6325.2023.04.0665

星形胶质细胞在中枢神经系统炎性疾病中作用的研究进展

李立亚¹, 秦霈^2*

1.大连医科大学附属第二医院麻醉科,辽宁大连 116007;
2.西安市儿童医院麻醉科,陕西西安 710003

收稿日期:2022-04-08 修回日期:2022-06-28 出版日期:2023-04-05 发布日期:2023-04-03
通讯作者: ^*xiaoqinnuli2011@126.com
基金资助:
国家自然科学基金青年项目(81901205)

Advances of researches on astrocytes in inflammatory diseases of central nervous system

LI Liya¹, QIN Pei^2*

1. Department of Anesthesiology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116007;
2. Department of Anesthesiology, Xi'an Children's Hospital, Xi'an 710003, China

Received:2022-04-08 Revised:2022-06-28 Online:2023-04-05 Published:2023-04-03
Contact: ^*xiaoqinnuli2011@126.com

摘要/Abstract

摘要： 星形胶质细胞应对多种中枢神经系统(CNS)损伤并活化为反应性星形胶质细胞,通过神经保护或神经毒性作用影响CNS的组织修复和神经炎性疾病的发生和发展。反应性星形胶质细胞的发生机制主要与其表型转化及下游炎性通路的激活相关。探索反应性星形胶质细胞的特征及其对CNS炎性疾病的调控机制可能为CNS炎性疾病的发病机制提供新见解和潜在干预靶点。

关键词: 反应性星形胶质细胞, 中枢神经系统, 神经炎性反应

Abstract: Astrocytes respond to various forms of central nervous system (CNS) damage which are activated to be reactive astrocytes and participate in tissue repairing, initiation and progression of neuroinflammatory diseases in CNS through neuroprotective or neurotoxic effects. The mechanism of reactive astrocytes is mainly related to their phenotypic transformation and activation of downstream inflammatory pathways. Exploring the characterization of reactive astrocytes and the underling mechanisms may provide unique insights into the pathogenesis of neuroinflammatory diseases and to identify potential targets of clinical treatment.

Key words: reactive astrocytes, central nervous system, neuroinflammation

中图分类号:

R392.3

李立亚, 秦霈. 星形胶质细胞在中枢神经系统炎性疾病中作用的研究进展[J]. 基础医学与临床, 2023, 43(4): 665-668.

LI Liya, QIN Pei. Advances of researches on astrocytes in inflammatory diseases of central nervous system[J]. Basic & Clinical Medicine, 2023, 43(4): 665-668.

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星形胶质细胞在中枢神经系统炎性疾病中作用的研究进展

Advances of researches on astrocytes in inflammatory diseases of central nervous system

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