诱导抑郁症患者小胶质细胞炎性反应的机制

doi:10.16352/j.issn.1001-6325.2024.07.1029

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (7): 1029-1033.doi: 10.16352/j.issn.1001-6325.2024.07.1029

诱导抑郁症患者小胶质细胞炎性反应的机制

张昊, 孙浩, 廖红^*

中国药科大学新药筛选与药效评价中心,江苏南京 210009

收稿日期:2024-03-15 修回日期:2024-05-21 出版日期:2024-07-05 发布日期:2024-06-26
通讯作者: ^*hliao@cpu.edu.cn
基金资助:
国家自然科学基金(82073831);重庆市自然科学基金(CSTB2023NSCQ-MSX0656);中国博士后科学基金(2023M733889)

Mechanism of inducing microglial inflammatory response in patients with depression

ZHANG Hao, SUN Hao, LIAO Hong^*

New Drug Screening and Pharmacodynamics Evaluation Center, China Pharmaceutical University, Nanjing 210009, China

Received:2024-03-15 Revised:2024-05-21 Online:2024-07-05 Published:2024-06-26
Contact: ^*hliao@cpu.edu.cn

摘要/Abstract

摘要： 小胶质细胞炎性反应是抑郁症患者及相关动物模型中广泛观察到的病理现象,与抑郁症密切相关。抑郁症中诱导小胶质细胞炎性反应的机制包括下丘脑-垂体-肾上腺(HPA)轴激活后糖皮质激素水平变化直接或间接的调控作用、肠道微生物代谢物通过脑肠轴中免疫与神经途径的作用以及损伤相关分子模式(DAMPs)对小胶质细胞的直接激活作用等。

关键词: 抑郁症, 小胶质细胞炎性反应, 下丘脑-垂体-肾上腺(HPA)轴, 脑肠轴, 损伤相关分子模式(DAMPs)

Abstract: Microglial inflammatory response is a pathological process frequently found in patients with depression and in animal models, which is believed to be closely related to depression. The potential mechanisms of inducing microglial inflammatory response by depression includes the direct or indirect regulation of glucocorticoid level changes after activation of the hypothalamic-pituitary-adrenal (HPA) axis, the effect of intestinal microbial metabolites through immune and neural pathways in the brain-gut axis, and the direct activation of damage associated molecular patterns (DAMPs) in microglia.

Key words: depression, microglial inflammatory response, hypothalamic-pituitary-adrenal (HPA) axis, gut-brain axis, damage associated molecular patterns (DAMPs)

中图分类号:

R749.4

张昊, 孙浩, 廖红. 诱导抑郁症患者小胶质细胞炎性反应的机制[J]. 基础医学与临床, 2024, 44(7): 1029-1033.

ZHANG Hao, SUN Hao, LIAO Hong. Mechanism of inducing microglial inflammatory response in patients with depression[J]. Basic & Clinical Medicine, 2024, 44(7): 1029-1033.

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诱导抑郁症患者小胶质细胞炎性反应的机制

Mechanism of inducing microglial inflammatory response in patients with depression

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