外泌体miRNAs在器官纤维化中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.09.1472

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (9): 1472-1476.doi: 10.16352/j.issn.1001-6325.2023.09.1472

外泌体miRNAs在器官纤维化中作用的研究进展

方路¹, 刘睿奇², 梁鹏¹, 岑瑛^2*

四川大学华西医院 1.全科医学中心日间手术中心;2.整形外科/烧伤科,四川成都 610041

收稿日期:2022-09-05 修回日期:2023-02-27 出版日期:2023-09-05 发布日期:2023-09-01
通讯作者: ^*cenying—pls@foxmail.com
基金资助:
四川省自然科学基金(2022NSFSC1395)

Progress on the role of exosomal miRNAs in organ fibrosis

FANG Lu¹, LIU Ruiqi², LIANG Peng¹, CEN Ying^2*

1. Department of Day Surgery Center, General Practice Medical Center; 2. Department of Burn and Plastic Surgery, West China Hospital of Sichuan University, Chengdu 610041, China

Received:2022-09-05 Revised:2023-02-27 Online:2023-09-05 Published:2023-09-01
Contact: ^*cenying—pls@foxmail.com

摘要/Abstract

摘要： 外泌体是由多种细胞主动分泌产生的可携带蛋白质、脂质、miRNAs等生物分子的微小囊泡。外泌体微小RNAs(miRNAs)稳定的存在于体液循环中,参与器官多项病理过程。在器官纤维化疾病中,外泌体miRNAs的含量与正常组织相比呈现出明显的差异性表达,通过调控不同信号通路促进或抑制器官纤维化。外泌体miRNAs可作为临床诊断器官纤维化及判断其纤维化程度的最新生物指标和纤维化疾病新的治疗靶点。

关键词: 外泌体, 外泌体miRNAs, 纤维化疾病

Abstract: Exosomes are tiny vesicles that are actively secreted by a variety of cells, which regulate various physiological and pathological processes of the body by carrying proteins, lipids, miRNAs and other biological molecules. Exocrine microRNAs(miRNAs) stably exist in the body fluid circulation and participate in many pathological processes of organs. In organ fibrosis disease, the content of the exosomal miRNAs shows significant differential expression profile as compared with normal tissues, and promotes or inhibits organ fibrosis by regulating different signal pathways. It is considered to be the latest biological indicator for diagnosing organ fibrosis and judging its degree of fibrosis, and a new therapeutic target for fibrosis disease.

Key words: exosome, exosomal miRNAs, fibrotic disease

中图分类号:

方路, 刘睿奇, 梁鹏, 岑瑛. 外泌体miRNAs在器官纤维化中作用的研究进展[J]. 基础医学与临床, 2023, 43(9): 1472-1476.

FANG Lu, LIU Ruiqi, LIANG Peng, CEN Ying. Progress on the role of exosomal miRNAs in organ fibrosis[J]. Basic & Clinical Medicine, 2023, 43(9): 1472-1476.

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外泌体miRNAs在器官纤维化中作用的研究进展

Progress on the role of exosomal miRNAs in organ fibrosis

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