外泌体在新型冠状病毒感染和传播中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.04.0680

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (4): 680-684.doi: 10.16352/j.issn.1001-6325.2023.04.0680

外泌体在新型冠状病毒感染和传播中作用的研究进展

崔诗雨^1,2, 张海峰^1,2*

西安交通大学 1.基础医学院病理学系,陕西西安 710061;
2.转化医学研究院遗传与发育研究所,陕西西安 710100

收稿日期:2022-02-11 修回日期:2022-06-05 出版日期:2023-04-05 发布日期:2023-04-03
通讯作者: ^*zhf19841011@xjtu.edu.cn
基金资助:
国家自然科学基金(81402312);中央高校基本科研业务费专项资金(xjj2018158);中国博士后科学基金(2014M552462)

Progress in the exosomes mediating SARS-CoV-2 infection and transmission

CUI Shiyu^1,2, ZHANG Haifeng^1,2*

1. Department of Pathology,Basic Medicine College, Xi'an Jiaotong University, Xi'an 710061;
2. Institute of Genetics and Developmental Biology, Translational Medicine Institute, Xi'an Jiaotong University, Xi'an 710100, China

Received:2022-02-11 Revised:2022-06-05 Online:2023-04-05 Published:2023-04-03
Contact: ^*zhf19841011@xjtu.edu.cn

摘要/Abstract

摘要： 外泌体在COVID-19的病理过程中起着重要作用,与其携带的核酸、蛋白质等物质,共同调控SARS-CoV-2的感染和传播。病毒感染细胞通过内体途径产生含SARS-CoV-2病毒颗粒的外泌体,介导病毒向健康细胞感染和传播,造成组织损伤和多器官功能障碍。同时,外泌体作为细胞间通讯的关键介质,起到免疫激活作用,促进机体产生免疫反应,抵抗病毒入侵。此外,外泌体协助病毒逃避机体免疫,是SARS-CoV-2再感染的潜在手段。总之,外泌体在新型冠状病毒感染和传播中的作用为其在诊断、防治COVID-19等方面的应用提供新思路。

关键词: 外泌体, SARS-CoV-2, COVID-19

Abstract: Exosomes play vital roles in the pathogenesis of COVID-19 infection. The infection and transmission of the disease is regulated by exosomes and their components, such as nucleic acids, proteins and other substances. The exosomes with COVID-19 particles are produced via the endosomal pathway from the infected cells, and mediate the viral infection and transmission to healthy cells, finally ending with the results of tissue damage and multiple organ dysfunctions. As the key mediators of intercellular communication, exosomes activate the immune system and enhance the response against virus invasion. In addition, COVID-19 may escape from immunity with the help of exosomes; this may be a potential way of reinfection. The role of exosomes in novel coronavirus infection and transmission provides important clues for the development of potential technology for the diagnosis and prevention.

Key words: exosomes, SARS-CoV-2, COVID-19

中图分类号:

R511

崔诗雨, 张海峰. 外泌体在新型冠状病毒感染和传播中作用的研究进展[J]. 基础医学与临床, 2023, 43(4): 680-684.

CUI Shiyu, ZHANG Haifeng. Progress in the exosomes mediating SARS-CoV-2 infection and transmission[J]. Basic & Clinical Medicine, 2023, 43(4): 680-684.

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外泌体在新型冠状病毒感染和传播中作用的研究进展

Progress in the exosomes mediating SARS-CoV-2 infection and transmission

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