肠易激综合征生物标志物的研究进展

doi:10.16352/j.issn.1001-6325.2023.03.500

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (3): 500-504.doi: 10.16352/j.issn.1001-6325.2023.03.500

肠易激综合征生物标志物的研究进展

郑行健¹, 冉雪¹, 任梓月¹, 戴迟兵^2*

1.三峡大学湖北宜昌 443002;
2.三峡大学附属仁和医院,湖北宜昌 443002

收稿日期:2021-11-01 修回日期:2022-04-15 出版日期:2023-03-05 发布日期:2023-02-27
通讯作者: * dchibing@126.com
基金资助:
湖北省卫生健康委科研项目(WJ2021F060)

Research progress on biomarkers of irritable bowel syndrome

ZHENG Xingjian¹, RAN Xue¹, REN Ziyue¹, DAI Chibing^2*

1. Three Gorges University, Yichang 443002;
2. Renhe Hospital Affiliated to Three Gorges University, Yichang 443002, China

Received:2021-11-01 Revised:2022-04-15 Online:2023-03-05 Published:2023-02-27
Contact: * dchibing@126.com

摘要/Abstract

摘要： 肠易激综合征 (IBS) 是一种功能性胃肠疾病,当前其诊断仍然沿用临床标准。与IBS发病相关的生物标志物有多种,IBS与平均血小板体积(MPV)、红细胞分布宽度(RDW)、中性粒细胞/淋巴细胞比值(NLR)、超敏C反应蛋白(HS-CRP)、C反应蛋白(CRP)、消退素 D1(RvD1)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、肿瘤坏死因子-α(TNF-α)、粪钙卫蛋白(FCP)、粪便乳铁蛋白(LF)相关。生物标志物可以减少结肠镜检查的使用,使IBS的诊断更加准确、快捷。

关键词: 肠易激综合征, 血清生物标志物, 粪便生物标志物, 罗马标准

Abstract: Irritable bowel syndrome (IBS) is a functional gastrointestinal disease, and its diagnostic criteria has been based on clinical profile. There are various biomarkers associated with IBS.This paper reviews the relationship between IBS and those biomarkers like mean platelet volume (MPV), red blood cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), high-sensitivity C-reactive protein (HS-CRP), C-reactive protein (CRP), resolvin D1 (RvD1), interleukin 6 (IL-6), interleukin 8(IL-8), tumor necrosis factor-α(TNF-α), fecal calprotectin (FCP), fecal lactoferrin (LF).The research and clinical application of valuable biomarkers for the diagnosis of IBS may make the diagnosis of IBS more accurate and faster,with less application of colonoscopy.

Key words: irritable bowel syndrome, serum biomarker, fecal biomarker, Roman standard

中图分类号:

R574.4

郑行健, 冉雪, 任梓月, 戴迟兵. 肠易激综合征生物标志物的研究进展[J]. 基础医学与临床, 2023, 43(3): 500-504.

ZHENG Xingjian, RAN Xue, REN Ziyue, DAI Chibing. Research progress on biomarkers of irritable bowel syndrome[J]. Basic & Clinical Medicine, 2023, 43(3): 500-504.

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肠易激综合征生物标志物的研究进展

Research progress on biomarkers of irritable bowel syndrome

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