免疫调节基因的多态性与Graves病易感性的相关性研究进展

doi:10.16352/j.issn.1001-6325.2023.03.495

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (3): 495-499.doi: 10.16352/j.issn.1001-6325.2023.03.495

免疫调节基因的多态性与Graves病易感性的相关性研究进展

王玉洁^1,2, 杨孟迪^1,2, 何风英^1,2, 丁雨露^1,2, 孙琳楠^1,2, 甄东户^2*

1.兰州大学第一临床医学院内分泌科,甘肃兰州 730030;
2.兰州大学第一医院内分泌科,甘肃兰州 730030

收稿日期:2021-11-04 修回日期:2022-05-07 出版日期:2023-03-05 发布日期:2023-02-27
通讯作者: * zhdh8279@163.com
基金资助:
上海市医药卫生发展基金会糖尿病临床研究项目(Ⅰ期10研究);标准化代谢性疾病管理中心(MMC)专项研究基金(2018-mmczxjj-3);甘肃省自然科学基金(21JR1RA096);甘肃省内分泌疾病临床医学研究中心(20JR10FA667)

Research progress on the correlation between polymorphism of immunoregulatory gene and susceptibility to Graves' disease

WANG Yujie^1,2, YANG Mengdi^1,2, HE Fengying^1,2, DING Yulu^1,2, SUN Linnan^1,2, ZHEN Donghu^2*

1. Department of Endocrinology,the First College of Clinical Medicine,Lanzhou University,Lanzhou 730030;
2. Department of Endocrinology,the First Hospital of Lanzhou University,Lanzhou 730030,China

Received:2021-11-04 Revised:2022-05-07 Online:2023-03-05 Published:2023-02-27
Contact: * zhdh8279@163.com

摘要/Abstract

摘要： Graves病(GD)是一种遗传背景强的器官特异性自身免疫性疾病,其核心发病环节是免疫因素,但遗传因素在其发病机制中也起到重要作用。GD的易感基因主要分为免疫调节基因和甲状腺特异性基因,其中免疫调节基因多态性可通过各种机制影响GD的易感性,故可为进一步研究GD的易感基因及发病机制提供新的思路。

关键词: Graves病, 易感基因, 基因多态性, 免疫调节基因

Abstract: Graves' disease(GD)is an organ-specific autoimmune disease with genetic background. The core pathogenesis of GD is immune factors, but genetic factors also play an important role in it. The susceptibility genes of GD are mainly divided into immunoregulatory gene and thyroid specific gene. The polymorphism of immunoregulatory gene may have some impact on the susceptibility of GD through various mechanisms, which may provide new ideas for the further study of the susceptibility genes and pathogenesis of GD.

Key words: Graves' disease, susceptibility gene, gene polymorphism, immunoregulatory gene

中图分类号:

R581.1

王玉洁, 杨孟迪, 何风英, 丁雨露, 孙琳楠, 甄东户. 免疫调节基因的多态性与Graves病易感性的相关性研究进展[J]. 基础医学与临床, 2023, 43(3): 495-499.

WANG Yujie, YANG Mengdi, HE Fengying, DING Yulu, SUN Linnan, ZHEN Donghu. Research progress on the correlation between polymorphism of immunoregulatory gene and susceptibility to Graves' disease[J]. Basic & Clinical Medicine, 2023, 43(3): 495-499.

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免疫调节基因的多态性与Graves病易感性的相关性研究进展

Research progress on the correlation between polymorphism of immunoregulatory gene and susceptibility to Graves' disease

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