胚胎发育生物标志物的研究进展

doi:10.16352/j.issn.1001-6325.2022.01.027

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 168-172.doi: 10.16352/j.issn.1001-6325.2022.01.027

胚胎发育生物标志物的研究进展

谢聪聪¹, 王雪莹¹, 安卓², 姚胜杰¹, 马婧¹, 王树松^1,2*

1.河北省计划生育科学技术研究院河北省生殖医院国家卫生健康委员会计划生育与优生重点实验室河北省生殖医学重点实验室,河北石家庄 050071;
2.河北医科大学研究生学院, 河北石家庄 050017

收稿日期:2021-02-03 修回日期:2021-06-03 出版日期:2022-01-05 发布日期:2022-01-05
通讯作者: ^* wshsong@sina.com
基金资助:
河北省医学科学研究课题(20210188)

Research progress on biomarkers for embryonic development

XIE Cong-cong¹, WANG Xue-ying¹, AN Zhuo², YAO Sheng-jie¹, MA Jing¹, WANG Shu-song^1,2*

1. Key Reproductive Medical Laboratory of Hebei Province, Key Laboratory for Family Planning and Birth Health of the National Health and Family Planning Committee, Hebei Reproductive Hospital, Research Institute of Family Planning of Hebei Province, Shijiazhuang 050071;
2. Graduate School of Hebei Medical University, Shijiazhuang 050017, China

Received:2021-02-03 Revised:2021-06-03 Online:2022-01-05 Published:2022-01-05
Contact: ^* wshsong@sina.com

摘要/Abstract

摘要： 筛选高质量配子和高发育潜能胚胎是辅助生殖技术关注的重点。近年研究发现胚胎培养液中含有胚胎分泌的蛋白、游离DNA片段、细胞因子等,胚胎也从培养液中获取胚胎发育所需的营养物质。通过分析胚胎培养液成分,运用无创的方法,利用胚胎代谢组学、蛋白组学等方法快速、准确筛选出最具有发育潜能的优质胚胎。本文总结氨基酸、碳水化合物、细胞因子和蛋白质等物质对胚胎发育的影响。

关键词: 胚胎, 培养液, 生物标志物, 氨基酸, 细胞因子

Abstract: Screenings high-quality gametes and high developmental potential embryos are focus of assisted reproductive technology. In recent years, studies have found that the embryo culture medium contains proteins secreted by the embryo, free DNA fragments, cytokines and so on, and the nutrients needed for embryo development are obtained from the culture medium. Through using non-invasive methods, for example embryo metabonomics, proteomics, to analyze the composition of the embryo culture medium. These biomarkers are helpful for rapid and accurate screening of high-quality embryos with the most developmental potential. This paper summarizes the effects of amino acids, carbohydrates, cytokines and proteins on embryonic development.

Key words: embryo, culture medium, biomarker, amino acid, cytokine

中图分类号:

R711.6

谢聪聪, 王雪莹, 安卓, 姚胜杰, 马婧, 王树松. 胚胎发育生物标志物的研究进展[J]. 基础医学与临床, 2022, 42(1): 168-172.

XIE Cong-cong, WANG Xue-ying, AN Zhuo, YAO Sheng-jie, MA Jing, WANG Shu-song. Research progress on biomarkers for embryonic development[J]. Basic & Clinical Medicine, 2022, 42(1): 168-172.

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胚胎发育生物标志物的研究进展

Research progress on biomarkers for embryonic development

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