基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 168-172.

• 短篇综述 • 上一篇    下一篇

胚胎发育生物标志物的研究进展

谢聪聪1,王雪莹2,安卓3,姚胜杰1,马婧1,王树松1   

  1. 1. 河北省计划生育科学技术研究院
    2. 河北省生殖医院
    3. 河北医科大学
  • 收稿日期:2021-02-03 修回日期:2021-05-31 出版日期:2022-01-05 发布日期:2022-01-05
  • 通讯作者: 王树松 E-mail:wshsong@sina.com
  • 基金资助:
    河北省医学科学研究课题

Research progress on biomarkers for embryonic development

  • Received:2021-02-03 Revised:2021-05-31 Online:2022-01-05 Published:2022-01-05
  • Contact: song shuwang E-mail:wshsong@sina.com

摘要: 筛选高质量配子和高发育潜能胚胎是辅助生殖技术关注的重点,近年研究发现胚胎培养液中含有胚胎分泌的蛋白,游离DNA片段,细胞因子等,并且从培养液中获取胚胎发育所需的营养物质,通过分析胚胎培养液成分,运用无创的方法,通过胚胎代谢组学,蛋白组学等生物标志物,有利于快速、准确筛选出最具有发育潜能的优质胚胎。本文总结氨基酸、碳水化合物、细胞因子和蛋白质等物质对胚胎发育的影响。

关键词: 关键词:胚胎, 培养液, 生物标志物, 氨基酸, 细胞因子

Abstract: Screening high-quality gametes and high developmental potential embryos is focus of assisted reproductive technology. In recent years, studies have found that the embryo culture medium contains proteins secreted by the embryo, free DNA fragments, cytokines and so on, and the nutrients needed for embryo development are obtained from the culture medium. Through Using non-invasive methods, for example embryo metabonomics, proteomics, to analyzed the composition of the embryo culture medium. These biomarkers are helpful for rapid and accurate screening of high-quality embryos with the most developmental potential. This paper summarizes the effects of amino acids, carbohydrates, cytokines and proteins on embryonic development.

Key words: Key words: embryo, culture medium, biomarker, amino acid, cytokine