Comparison between the MIND-China study and similar international large-scale cohort studies

doi:10.3969/j.issn.1672-6731.2026.02.006

Abstract

Abstract: Alzheimer's disease(AD) continuum is characterized by an insidious onset and a continuous disease spectrum, making early identification particularly challenging. Its initiation and progression result from complex interactions among amyloid β-protein(Aβ) and microtuble-associated protein tau pathologies, vascular factors, genetic susceptibility, and other multifactorial mechanisms.Achieving precise staging across the AD continuum and implementing timely interventions are pivotal to delaying disease progression. Centered on the Multimodal Interventions to Delay Dementia and Disability in Rural China(MIND-China) study, contextualized within evidence from similar international large-scale cohort studies, this article systematically reviews the epidemiological characteristics, risk factors, imaging characteristics, multimodal biological markers, emerging intervention strategies, and looking ahead to future development directions across the AD continuum. The aim is provide an evidence-based medical evidence for formulating an early identification, risk stratification and comprehensive prevention and control system for Alzheimer's disease that suits China's national conditions.

Key words: Alzheimer disease, Cohort studies, China, Epidemiological monitoring, Risk factors, Biomarkers, Early diagnosis, Review

摘要： 阿尔茨海默病连续疾病谱起病隐匿，早期识别困难，其发生发展涉及β-淀粉样蛋白和微管相关蛋白tau蛋白病理以及血管和遗传等多因素复杂交互作用。实现对疾病谱的精准分期与早期干预，是延缓阿尔茨海默病进展的关键策略。本文全景回顾中国农村老年人延缓痴呆和失能的多模态干预（MIND-China）研究结果，并与国际同类大型队列研究对照，系统梳理我国农村地区及中低等收入人群阿尔茨海默病连续疾病谱的流行病学特征、危险因素、影像学特征、多模态生物学标志物、临床干预新策略并展望未来发展方向，旨在为制定符合中国国情的阿尔茨海默病早期识别、风险分层与综合防控体系提供循证医学证据。

关键词: 阿尔茨海默病, 队列研究, 中国, 流行病学监测, 危险因素, 生物标记, 早期诊断, 综述

CLC Number:

R741

WANG Xiao-yu, DU Yi-feng. Comparison between the MIND-China study and similar international large-scale cohort studies[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2026, 26(2): 152-160.

王晓宇, 杜怡峰. MIND-China研究与国际同类研究的对照[J]. 中国现代神经疾病杂志, 2026, 26(2): 152-160.

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https://journal11.magtechjournal.com/cjcnn/EN/Y2026/V26/I2/152

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