Progress on limbic-predominant age-related TDP-43 encephalopathy

doi:10.3969/j.issn.1672-6731.2025.09.013

Abstract

Abstract:

Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a common neurodegenerative disease primarily affecting the oldest old, characterized by pathological TDP-43 protein deposition. Pure LATE manifests as slowly progressive amnestic symptoms. Antemortem diagnosis of this disease is challenging, with definitive diagnosis heavily reliant on postmortem pathological examination. Consequently, research into treatments for this disease has lagged behind. This review aims to summarize recent advances in the clinical manifestations, pathological characteristic and biomarkers of LATE, with the goal of enhancing understanding of the disease.

Key words: Neurodgenerative diseases, Limbic system, Biomarkers, Pathology, Review

摘要：

边缘叶为主年龄相关性TDP-43脑病(LATE)是一种常见于高龄老年人群的神经系统变性疾病, 以病理性TDP-43蛋白沉积为特征, 单纯LATE表现为缓慢进展的遗忘综合征, 生前诊断困难, 明确诊断高度依赖尸检病理, 疾病治疗研究相对滞后。本研究拟对近年LATE在临床特征、病理学特点、生物学标志物等方面的进展进行综述, 以期提高临床对疾病的认识。

关键词: 神经变性疾病, 边缘系统, 生物标记, 病理学, 综述

Yuan-yuan WANG, Yang GAO, Cui ZHAO, Ming-wei ZHU, Zhen-fu WANG. Progress on limbic-predominant age-related TDP-43 encephalopathy[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2025, 25(9): 862-868.

王圆圆, 高阳, 赵翠, 朱明伟, 王振福. 边缘叶为主年龄相关性TDP-43脑病研究进展[J]. 中国现代神经疾病杂志, 2025, 25(9): 862-868.

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URL: https://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2025.09.013

https://journal11.magtechjournal.com/cjcnn/EN/Y2025/V25/I9/862

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