中国现代神经疾病杂志 ›› 2017, Vol. 17 ›› Issue (11): 851-855. doi: 10.3969/j.issn.1672-6731.2017.11.013

• 综述 • 上一篇    下一篇

2 小纤维神经病诊断研究进展

冼凯莉, 杜宝新   

  1. 510006 广州中医药大学第二临床医学院研究生院2014级(冼凯莉);510006 广州,广东省中医院脑病科(杜宝新)
  • 出版日期:2017-11-25 发布日期:2017-11-29
  • 通讯作者: 杜宝新(Email:dbx.dr@163.com)
  • 基金资助:

    2014 年度广东省中医药局科研课题(项目编号:20141140);2014 年度广东省中医院(广东省中医药科学院)中医临床评价研究专项课题(项目编号:YN2014PJ06)

Research progress of the diagnosis of small fiber neuropathy

XIAN Kai-li1, DU Bao-xin2   

  1. 1Grade 2014, Graduate School, the Second Clinical Medicine College, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China
    2Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China
  • Online:2017-11-25 Published:2017-11-29
  • Contact: DU Bao-xin (Email: dbx.dr@163.com)
  • Supported by:

    This study was supported by 2014 Guangdong Traditional Chinese Medicine Bureau Funding Research Project (No. 20141140) and 2014 Guangdong Provincial Hospital of Chinese Medicine (Guangdong Academy of Traditional Chinese Medicine) Clinical Evaluation Research Project (No. YN2014PJ06).

摘要:

小纤维神经病系指主要累及小直径有髓鞘Aδ类纤维和无髓鞘C 类纤维的一组疾病,典型表现为异常疼痛、痛温觉缺失和自主神经功能障碍。神经传导速度检测可以检出大纤维(Aα类和Aβ类纤维)病变,而无法评价小纤维功能。本文拟对近年来小纤维神经病的神经病理学、神经电生理学和自主神经功能检测等筛查和诊断方法研究进展进行简要概述。

关键词: 小纤维神经病, 诊断, 综述

Abstract:

Small fiber neuropathy (SFN) is a kind of peripheral neuropathy in which the thinly myelinated A δ fibers and unmyelinated C fibers are predominantly affected, characterized by allodynia, analgesia, thermoanesthesia and/or autonomic nerve dysfunction. Nerve conduction velocity (NCV) detection can detect the pathological changes of large fibers (Aα and Aβ fibers) but not of small fibers, which lack of value in the diagnosis of SFN. Progress of the examinational and diagnostic methods for the neuropathological, neuroelectrophysiological and autonomic nerve functions of SFN in recent years were introduced in this paper.

Key words: Small fiber neuropathy, Diagnosis, Review