摘要：

帕金森病是中老年人群常见的神经变性病，认知功能障碍是其最常见的非运动症状，严重影响患者生活质量。认知功能障碍与多种因素有关，如脑白质高信号，且脑白质高信号是帕金森病认知功能障碍的重要病理改变。本文从神经元通路、脑白质体积变化和扩散张量成像方面阐述脑白质高信号与帕金森病认知功能障碍之间的关系，为早期诊断帕金森病提供新的方向。

关键词: 帕金森病, 认知障碍, 磁共振成像, 综述

Abstract:

Parkinson's disease (PD) is a common neurodegenerative disease in the elderly, of which cognitive impairment is the most common non-motor symptom (NMS) affecting the life quality of patients. Cognitive impairment is associated with many factors, and white matter hyperintensity (WMH) is an important pathological change of cognitive impairment in PD. In this paper, we will explain the relationship between WMH and cognitive impairment in PD by the perspective of neuronal pathway, white matter volume change and diffusion tensor imaging (DTI), to provide a new direction for the early diagnosis of PD.

Key words: Parkinson disease, Cognition disorders, Magnetic resonance imaging, Review