摘要:
阿尔茨海默病为痴呆常见病因,占所有痴呆类型的60% ~ 80%。遗传因素和非遗传因素可能共同参与阿尔茨海默病的发病,以遗传因素起决定作用。阿尔茨海默病相关基因包括β-淀粉样前体蛋白(APP)、早老素1 和2(PS-1 和PS-2)、载脂蛋白Eε4(ApoEε4)等位基因;非遗传因素以血管性危险因素为常见病因,包括高血压、糖尿病、高胆固醇血症、吸烟、饮酒、肥胖、颅内动脉粥样硬化、心房颤动和脑血管病等。本文选择中国学者近5 年来发表在国外杂志的关于阿尔茨海默病与血管性危险因素关系的3项高质量前瞻性队列研究,重点介绍其研究方法和结果。
关键词:
阿尔茨海默病,
危险因素,
综述
Abstract:
Alzheimer's disease (AD) is the most common cause of dementia, accounting for 60% to 80% of all types of dementia. Both genetic and non-genetic factors may take part in the etiopathogenesis of AD. Among them, genetic factors play a decisive role in the development of AD. Gene mutations associated with AD include amyloid β-protein precursor (APP), presenilin-1 (PS-1), presenilin-2 (PS-2) and apolipoprotein Eε4 (ApoEε4) allele gene. Vascular risk factors are the most common causes in non-genetic factors, such as hypertension, diabetes, hypercholesterolemia, smoking, drinking, obesity, intracranial arteriosclerosis, atrial fibrillation and cerebrovascular diseases. We selected three high-quality prospective cohort studies regarding the association of AD with vascular risk factors in Chinese population which were published in foreign journals during the past 5 years, and focused on study methods and results.
Key words:
Alzheimer disease,
Risk factors,
Review
李娅, 龙慧, 楚兰, 刘芳, 田田, 贺电. 阿尔茨海默病与血管性危险因素关系研究:中国学者海外报道[J]. 中国现代神经疾病杂志, 2015, 15(7): 518-523.
LI Ya, LONG Hui, CHU Lan, LIU Fang, TIAN Tian, HE Dian. Studies on the association between Alzheimer's disease and vascular risk factors: reports from China[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2015, 15(7): 518-523.