摘要： 外科手术切除致灶的大力开展，为难治性癫痫的神经病理学研究提供了充足的病例资源。近年来，国际上关于皮质发育畸形和海马硬化的分类均有了新的研究成果和共识，同时结合分子生物学和分子遗传学的探索为我们认识癫痫相关病变的疾病谱系和发病机制提供了新的依据。未来几年，关于致灶的分子病理学及其致痫性的研究将成为热点。

关键词: 癫痫, 颞叶, 皮质发育畸形, 海马, 病理学, 综述

Abstract: With increased surgical operation samples of intractable epilepsy, there are sufficient cases for neuropathological study. Some new studies and consensus on classification of malformations of cortical development or hippocampal sclerosis were proposed recently. Moreover, researches using molecular and genetic methods have provided new opinions for disease spectrum and pathogenesis of epilepsy associated lesions. In the next few years, further studies on the molecular pathology and epileptogenesis of the epileptic foci are necessary.

Key words: Epilepsy, temporal lobe, Malformations of cortical development, Hippocampus, Pathology, Review