中国现代神经疾病杂志 ›› 2025, Vol. 25 ›› Issue (3): 265-270. doi: 10.3969/j.issn.1672-6731.2025.03.014

• 综述 • 上一篇    

2 Rasmussen脑炎发病机制及治疗进展

吴红梅1, 季涛云2, 张继新1,*()   

  1. 1. 100034 北京大学第一医院病理科(吴红梅、张继新)
    2. 100034 北京大学第一医院病理科儿科(季涛云)
  • 收稿日期:2025-02-07 出版日期:2025-03-25 发布日期:2025-04-21
  • 通讯作者: 张继新
  • 基金资助:
    国家重点研发计划项目(2022YFC2705205); 中央高水平医院临床科研业务费资助项目(2024IR23)

Research progress on pathogenesis and treatment of Rasmussen encephalitis

Hong-mei WU1, Tao-yun JI2, Ji-xin ZHANG1,*()   

  1. 1. Department of Pathology, Peking University First Hospital, Beijing 100034, China
    2. Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
  • Received:2025-02-07 Online:2025-03-25 Published:2025-04-21
  • Contact: Ji-xin ZHANG
  • Supported by:
    National Key Research and Development Program of China(2022YFC2705205); National High Level Hospital Clinical Research Funding(2024IR23)

摘要:

Rasmussen脑炎的发病机制尚未明确, 目前病毒感染机制、抗体介导的体液免疫机制、T淋巴细胞介导的细胞免疫机制及小胶质细胞介导的神经退行性变机制可能与疾病发生发展过程相关。疾病早期针对T淋巴细胞和小胶质细胞的免疫治疗可延缓部分患者疾病进展。本文对Rasmussen脑炎主要发病机制学说和最新治疗进展进行综述, 以提高临床对疾病的认识, 并为治疗提供指导。

关键词: 脑炎, 癫痫, 病理学, 免疫疗法, 综述

Abstract:

The pathogenesis of Rasmussen encephalitis (RE) remains unclear. Current theories suggest that viral infection, antibody-mediated humoral immune mechanisms, T lymphocytes mediated cellular immunity, and microglia mediated neurodegeneration may all be involved in disease onset and progression. In the early stage of disease, immunotherapy targeting induced by T lymphocytes and microglia could slow down disease progression of some patients. This review summarizes the latest research on the main pathogenic hypotheses and treatment strategies for RE, aiming to enhance clinical understanding of the disease and provide guidance for therapeutic interventions.

Key words: Encephalitis, Epilepsy, Pathology, Immunotherapy, Review