摘要：

最新研发的抗Aβ单克隆抗体陆续在国内外获批上市，并逐渐应用于我国临床实践。为促进抗Aβ单克隆抗体在我国阿尔茨海默病治疗中更合理、安全的应用，本文结合抗Aβ单克隆抗体现有临床试验证据及阿杜卡单抗在上海交通大学医学院附属瑞金医院海南医院的临床应用经验，总结抗Aβ单克隆抗体的临床应用建议，包括临床用药指征、用药前评估及准备、用药时医嘱及注意事项、用药后临床监测，旨在为临床医师提供翔实的用药指导和建议。

关键词: 阿尔茨海默病, 淀粉样β肽类, 抗体，单克隆, 诊疗指南, 综述

Abstract:

Several anti-Aβ monoclonal antibody drugs have been approved for clinical use at home and abroad recently. In order to facilitate its safe and effective treatment of anti-Aβ monoclonal antibody drugs for Alzheimer's disease (AD) in China, we present recommendations for the clinical use of anti-Aβ monoclonal antibody drugs based on existing clinical trials and the clinical practice of AD treatment with Aducanumab at Ruijin Hospital Hainan Branch, Shanghai Jiaotong University School of Medicine. The recommendations include clinical indications, pre-medication assessment and preparation, medication instructions and precautions, as well as post-medication clinical monitoring, which is aimed to furnish clinicians with comprehensive medication guidance.

Key words: Alzheimer disease, Amyloid beta-peptides, Antibodies, monoclonal, Diagnostic and treatment guideline, Review