中国现代神经疾病杂志 ›› 2022, Vol. 22 ›› Issue (1): 46-53. doi: 10.3969/j.issn.1672-6731.2022.01.007

• 炎症与神经系统疾病 • 上一篇    下一篇

2 缺血性卒中免疫学研究进展

樊泽新, 刘广志   

  1. 100029 首都医科大学附属北京安贞医院神经内科
  • 收稿日期:2022-01-09 出版日期:2022-01-25 发布日期:2022-01-22
  • 通讯作者: 刘广志,Email:guangzhi2002@hotmail.com E-mail:guangzhi2002@hotmail.com
  • 基金资助:
    国家自然科学基金资助项目(项目编号:82071342)

Advances in immunology of ischemic stroke

FAN Ze-xin, LIU Guang-zhi   

  1. Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
  • Received:2022-01-09 Online:2022-01-25 Published:2022-01-22
  • Supported by:
    This study was supported by the National Natural Science Foundation of China (No. 82071342)

摘要: 缺血性卒中的病理生理学过程是复杂的、多因素(遗传因素和免疫因素等)参与的免疫炎症反应过程,具有多相性特点,既包括促炎症反应,又包括抗炎症反应,且炎性因子和炎性细胞的表达变化及其效应呈时间依赖性,从而发挥神经损伤或神经保护作用。本文综述缺血性卒中相关免疫学研究进展。

关键词: 卒中, 脑缺血, 变态反应和免疫学, 综述

Abstract: The pathophysiological process of ischemic stroke is a complex inflammatory process involving multiple factors (genetic factors, immune factors, etc.). Its inflammatory response is multiphasic, with both pro - inflammatory and anti - inflammatory reactions. Moreover, the changes and effects of inflammatory cells and cytokines are time - dependent, thus exerting neurodestruction or neuroprotection. This article reviews the research progress of ischemic stroke-related immunology in recent years.

Key words: Stroke, Brain ischemia, Allergy and immunology, Review