摘要：

衰弱作为一种老年综合征，使老年人不良健康结果如跌倒、抑郁、残疾、失能和死亡等增加，其发病机制尚未明确，慢性炎症被认为是其发生发展的主要机制。炎症反应通过导致肌少症、肥胖、多种慢性病以及免疫功能下降等病理生理学机制而诱发衰弱。营养支持、药物治疗和运动干预等措施可降低炎性因子水平，减轻炎症反应，从而促进肌肉生长、减少肥胖，对衰弱有一定改善作用。

关键词: 炎症, 蛋白质能量营养不良, 综述

Abstract:

Frailty, as a kind of geriatric syndrome, increases adverse health outcomes such as falls, depression, deformity, disability and death in the elderly. The pathogenesis of frailty is not yet clear, and chronic inflammation is considered to be the main mechanism for its occurrence and development. Inflammation induces frailty by leading to sarcopenia, obesity, a variety of chronic diseases and immune dysfunction. Nutrition support, drug therapy and exercise intervention can reduce the level of inflammatory factors, reduce the inflammatory response, thus promoting muscle growth, reduce obesity, have a certain improvement effect on frailty.

Key words: Inflammation, Protein-energy malnutrition, Review