自身免疫性脑炎相关癫癎功能影像学研究进展

doi:10.3969/j.issn.1672-6731.2020.01.003

中国现代神经疾病杂志 ›› 2020, Vol. 20 ›› Issue (1): 9-14. doi: 10.3969/j.issn.1672-6731.2020.01.003

• 神经系统疾病免疫研究进展 • 上一篇下一篇

2 自身免疫性脑炎相关癫癎功能影像学研究进展

刘霄¹, 单伟^1,2, 张玉笛¹, 吕瑞娟¹, 王群^1,2

1. 100070 首都医科大学附属北京天坛医院神经病学中心癫痫科国家神经系统疾病临床医学研究中心;
2. 100069 北京脑重大疾病研究院

收稿日期:2020-01-10 出版日期:2020-01-25 发布日期:2020-01-21
通讯作者: 王群,Email:wangq@ccmu.edu.cn
基金资助:
国家重点研发计划项目（项目编号：2017YFC1307501）；京津冀基础研究合作专项项目（项目编号：H2018206435）；首都卫生发展科研专项项目（项目编号：首发2016-1-2011）

Progress in functional imaging of autoimmune encephalitis associated with epilepsy

LIU Xiao¹, SHAN Wei^1,2, ZHANG Yu-di¹, Lü Rui-juan¹, WANG Qun^1,2

1 Department of Epilepsy, Neurology Center, Beijing Tiantan Hospital, Capital Medical University;China National Clinical Research Center for Neurological Diseases, Beijing 100070, China;
2 Beijing Institute for Brain Disorders, Beijing 100069, China

Received:2020-01-10 Online:2020-01-25 Published:2020-01-21
Supported by:
This study was supported by National Key Research and Development Program of China (No. 2017YFC1307501), Beijing-Tianjin-Hebei Cooperative Basic Research Special Program (No. H2018206435), and Capital Health Development and Research Project (No. 2016-1-2011).

摘要/Abstract

摘要：

自身免疫性脑炎相关癫癎是一组重要的临床综合征，主要表现为难治性癫癎发作、认知功能障碍和精神症状，经早期诊断和免疫治疗后可获得良好预后，因此尽早诊断、及时治疗至关重要。随着神经影像学技术特别是功能影像学的发展，逐渐显现出显著的临床应用价值，在疾病诊断和预后评估中具有重要作用。通过综述国内外自身免疫性脑炎相关癫癎功能影像学研究进展，为早期识别、鉴别诊断和预后评估提供影像学依据。

关键词: 自身免疫疾病, 脑炎, 癫癎, 正电子发射断层显像术, 综述

Abstract:

Autoimmune encephalitis (AE) associated with epilepsy is a significant clinical syndrome, which is characterized by refractory seizures, cognitive deficits, neuropsychiatric disturbances. Many studies have been clearly notified that early diagnosis combined with immunotherapy can apparently improve prognosis, thus early diagnosis and treatment are highly essential. In recent years, the neuroimaging, especially functional imaging, plays a critical role in the early diagnosis and prognostic assessment of AE associated with epilepsy. This review summarized the methods and results of functional imaging in the diagnosis of epilepsy associated with AE, to provide an imaging basis for clinical and differential diagnosis and prognostic assessment.

Key words: Autoimmune diseases, Encephalitis, Epilepsy, Positron-emission tomography, Review

刘霄, 单伟, 张玉笛, 吕瑞娟, 王群. 自身免疫性脑炎相关癫癎功能影像学研究进展[J]. 中国现代神经疾病杂志, 2020, 20(1): 9-14.

LIU Xiao, SHAN Wei, ZHANG Yu-di, Lü Rui-juan, WANG Qun. Progress in functional imaging of autoimmune encephalitis associated with epilepsy[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(1): 9-14.

https://journal11.magtechjournal.com/cjcnn/CN/Y2020/V20/I1/9

参考文献

[1] Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM. ILAE classification of the epilepsies:position paper of the ILAE commission for classification and terminology[J]. Epilepsia, 2017, 58:512-521.
[2] Levite M. Autoimmune epilepsy[J]. Nat Immunol, 2002, 3:500.
[3] Dalmau J, Tüzün E, Wu HY, Masjuan J, Rossi JE, Voloschin A, Baehring JM, Shimazaki H, Koide R, King D, Mason W, Sansing LH, Dichter MA, Rosenfeld MR, Lynch DR. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma[J]. Ann Neurol, 2007, 61:25-36.
[4] Greco A, Rizzo MI, De Virgilio A, Conte M, Gallo A, Attanasio G, Ruoppolo G, de Vincentiis M. Autoimmune epilepsy[J]. Autoimmun Rev, 2016, 15:221-225.
[5] Morbelli S, Djekidel M, Hesse S, Pagani M, Barthel H; Neuroimaging Committee of the European Association of Nuclear Medicine (EANM), Brain Imaging Council of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). Role of ¹⁸F-FDG-PET imaging in the diagnosis of autoimmune encephalitis[J]. Lancet Neurol, 2016, 15:1009-1010.
[6] Morbelli S, Arbizu J, Booij J, Chen MK, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Jafari L, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H; European Association of Nuclear Medicine (EANM) and of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). The need of standardization and of large clinical studies in an emerging indication of[¹⁸F]FDG PET:the autoimmune encephalitis[J]. Eur J Nucl Med Mol Imaging, 2017, 44:353-357.
[7] Yuan J, Guan H, Zhou X, Niu N, Li F, Cui L, Cui R. Changing brain metabolism patterns in patients with ANMDARE:serial ¹⁸F-FDG PET/CT findings[J]. Clin Nucl Med, 2016, 41:366-370.
[8] Zhang X, Chen XJ, Li X, Ge JJ, Zuo CT. The 2-[¹⁸F] fluoro-2-deoxy-D-glucose PET-CT manifestations of patients with anti-N-methyl-D-aspartate receptorencephalitis at different stages[J]. Zhonghua Shen Jing Ke Za Zhi, 2015, 48:84-88.[张祥, 陈向军,李翔, 葛璟洁, 左传涛. 抗N-甲基-D-天冬氨酸受体脑炎患者不同时期的脑PET-CT显像[J]. 中华神经科杂志, 2015, 48:84-88.]
[9] Probasco JC, Solnes L, Nalluri A, Cohen J, Jones KM, Zan E, Javadi MS, Venkatesan A. Decreased occipital lobe metabolism by FDG-PET/CT:an anti-NMDA receptor encephalitis biomarker[J]. Neurol Neuroimmunol Neuroinflamm, 2017, 5:E413.
[10] Leypoldt F, Buchert R, Kleiter I, Marienhagen J, Gelderblom M, Magnus T, Dalmau J, Gerloff C, Lewerenz J. Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis:distinct pattern of disease[J]. J Neurol Neurosurg Psychiatry, 2012, 83:681-686.
[11] Moubtakir A, Dejust S, Godard F, Messaoud L, Morland D. ¹⁸F-FDG PET/CT in anti-NMDA receptor encephalitis:typical pattern and follow-up[J]. Clin Nucl Med, 2018, 43:520-521.
[12] Llorens V, Gabilondo I, Gómez-Esteban JC, Agundez M, Mendibe M, Bergara JC, Ciordia R, Saiz A, Zarranz JJ. Abnormal multifocal cerebral blood flow on Tc-99m HMPAO SPECT in a patient with anti-NMDA-receptor encephalitis[J]. J Neurol, 2010, 257:1568-1569.
[13] Finke C, Kopp UA, Scheel M, Pech LM, Soemmer C, Schlichting J, Leypoldt F, Brandt AU, Wuerfel J, Probst C, Ploner CJ, Prüss H, Paul F. Functional and structural brain changes in anti-N-methyl-D-aspartate receptor encephalitis[J]. Ann Neurol, 2013, 74:284-296.
[14] Lai M, Huijbers MG, Lancaster E, Graus F, Bataller L, Balice-Gordon R, Cowell JK, Dalmau J. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels:a case series[J]. Lancet Neurol, 2010, 9:776-785.
[15] Shin YW, Lee ST, Shin JW, Moon J, Lim JA, Byun JI, Kim TJ, Lee KJ, Kim YS, Park KI, Jung KH, Lee SK, Chu K. VGKC-complex/LGI1-antibody encephalitis:clinical manifestations and response to immunotherapy[J]. J Neuroimmunol, 2013, 265:75-81.
[16] Wegner F, Wilke F, Raab P, Tayeb SB, Boeck AL, Haense C, Trebst C, Voss E, Schrader C, Logemann F, Ahrens J, Leffler A, Rodriguez-Raecke R, Dengler R, Geworski L, Bengel FM, Berding G, Stangel M, Nabavi E. Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18 F-fluoro-2-deoxy-d-glucose positron emission tomography[J]. BMC Neurol, 2014, 14:136.
[17] Kunze A, Drescher R, Kaiser K, Freesmeyer M, Witte OW, Axer H. Serial FDG PET/CT in autoimmune encephalitis with faciobrachial dystonic seizures[J]. Clin Nucl Med, 2014, 39:E436-438.
[18] Takkar A, Choudhary A, Ram Mittal B, Lal V. Reversible bilateral striatal hypermetabolism in a patient with leucine-rich glioma inactivated-1 encephalitis[J]. J Clin Neurol, 2016, 12:519-520.
[19] He FF, Ye J, Xu WD. Clinical characteristics of leucine-rich glioma-inactivated protein 1 antibody-associated encephalitis[J]. Zhonghua Shen Jing Ke Za Zhi, 2016, 49:26-29.[贺菲菲, 叶静, 徐文灯. 富亮氨酸胶质瘤失活1蛋白抗体脑炎的临床特点[J]. 中华神经科杂志, 2016, 49:26-29.]
[20] Heine J, Prüss H, Kopp UA, Wegner F, Then Bergh F, Münte T, Wandinger KP, Paul F, Bartsch T, Finke C. Beyond the limbic system:disruption and functional compensation of large-scale brain networks in patients with anti-LGI1 encephalitis[J]. J Neurol Neurosurg Psychiatry, 2018, 89:1191-1199.
[21] Chen Y, Xing XW, Zhang JT, Wang RX, Zhao W, Tan QC, Liu RZ, Wang XQ, Huang XS, Yu SY. Autoimmune encephalitis mimicking sporadic Creutzfeldt-Jakob disease:a retrospective study[J]. J Neuroimmunol, 2016, 295/296:1-8.
[22] Baumgartner A, Rauer S, Mader I, Meyer PT. Cerebral FDG-PET and MRI findings in autoimmune limbic encephalitis:correlation with autoantibody types[J]. J Neurol, 2013, 260:2744-2753.
[23] Toosy AT, Burbridge SE, Pitkanen M, Loyal AS, Akanuma N, Laing H, Kopelman MD, Andrews TC. Functional imaging correlates of fronto-temporal dysfunction in Morvan's syndrome[J]. J Neurol Neurosurg Psychiatry, 2008, 79:734-735.
[24] Lancaster E, Lai M, Peng X, Hughes E, Constantinescu R, Raizer J, Friedman D, Skeen MB, Grisold W, Kimura A, Ohta K, Iizuka T, Guzman M, Graus F, Moss SJ, Balice-Gordon R, Dalmau J. Antibodies to the GABA(B) receptor in limbicencephalitis with seizures:case series and characterisation of the antigen[J]. Lancet Neurol, 2010, 9:67-76.
[25] Kim TJ, Lee ST, Shin JW, Moon J, Lim JA, Byun JI, Shin YW, Lee KJ, Jung KH, Kim YS, Park KI, Chu K, Lee SK. Clinical manifestations and outcomes of the treatment of patients with GABAB encephalitis[J]. J Neuroimmunol, 2014, 270(1/2):45-50.
[26] Wang CC, Zhang YX, Yang HL, Wu YY, Shi YY, Gao XY, Xu CS, Zhao JH, Hu YM, Shi XH, Zhang JW. Clinical features of anti γ-aminobutyric acid B receptor encephalitis[J]. Zhonghua Shen Jing Yi Xue Za Zhi, 2017, 16:938-942.[王灿灿, 张元杏,杨辉丽, 吴颖颖, 时英英, 高鑫雅, 徐长水, 赵建华, 胡亚梅, 史晓红, 张杰文. 抗γ-氨基丁酸B受体脑炎临床特点分析[J]. 中华神经医学杂志, 2017, 16:938-942.]
[27] Su M, Xu D, Tian R. (18)F-FDG PET/CT and MRI findings in a patient with anti-GABA(B) receptor encephalitis[J]. Clin Nucl Med, 2015, 40:515-517.
[28] Ohta K, Seki M, Dalmau J, Shinohara Y. Perfusion IMP-SPECT shows reversible abnormalities in GABA(B) receptor antibody associated encephalitis with normal MRI[J]. Brain Behav, 2011, 1:70-72.
[29] Qiao S, Zhang YX, Zhang BJ, Lu RY, Lai QL, Chen LH, Wu J. Clinical, imaging, and follow-up observations of patients with anti-GABAB receptor encephalitis[J]. Int J Neurosci, 2017, 127:379-385.
[30] Lai M, Hughes EG, Peng X, Zhou L, Gleichman AJ, Shu H, Matà S, Kremens D, Vitaliani R, Geschwind MD, Bataller L, Kalb RG, Davis R, Graus F, Lynch DR, BaliceGordon R, Dalmau J. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location[J]. Ann Neurol, 2009, 65:424-434.
[31] Spatola M, Stojanova V, Prior JO, Dalmau J, Rossetti AO. Serial brain 18 FDG-PET in anti-AMPA receptor limbic encephalitis[J]. J Neuroimmunol, 2014, 271(1/2):53-55.
[32] Laurido-Soto O, Brier MR, Simon LE, McCullough A, Bucelli RC, Day GS. Patient characteristics and outcome associations in AMPA receptor encephalitis[J]. J Neurol, 2019, 266:450-460.
[33] Kojima G, Inaba M, Bruno MK. PET-positive extralimbic presentation of anti-glutamic acid decarboxylase antibody-associated encephalitis[J]. Epileptic Disord, 2014, 16:358-361.
[34] Ouyang M, Zhou Q, Li H, Hu X, Fei LX, Jin Y, Zhang PQ, Li DF, Li KH, Kuang ZY, Zhou JH. Clinical study of GAD antibody-related autoimmune epilepsy[J]. Dian Xian Yu Shen Jing Dian Sheng Li Xue Za Zhi, 2019, 28:65-71.[欧阳梅, 周青, 李花, 胡湘, 费凌霞, 金洋, 张佩琪, 李淡芳, 李恺辉, 匡祖颖, 周锦华. GAD抗体相关自身免疫性脑炎相关癫痫的临床研究[J]. 癫痫与神经电生理学杂志, 2019, 28:65-71.]

选择文件类型/文献管理软件名称

选择包含的内容

2 自身免疫性脑炎相关癫癎功能影像学研究进展

Progress in functional imaging of autoimmune encephalitis associated with epilepsy

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	佟志勇. 颅内动脉瘤与脑血管重建术[J]. 中国现代神经疾病杂志, 2024, 24(8): 595-598.
[2]	佟志勇. 脑血管重建术历史沿革[J]. 中国现代神经疾病杂志, 2024, 24(8): 599-605.
[3]	金凌骥, 胡俊文, 李寅, 王林. 复杂颅内动脉瘤的颅内-颅内血管搭桥术[J]. 中国现代神经疾病杂志, 2024, 24(8): 606-612.
[4]	刘佩玺, 史源, 朱巍. 血流导向时代颅内全域脑血管搭桥术治疗颅内动脉瘤之应用方略[J]. 中国现代神经疾病杂志, 2024, 24(8): 613-618.
[5]	张峰, 孟凡刚. 帕金森病自主神经功能障碍丘脑底核脑深部电刺激术治疗进展[J]. 中国现代神经疾病杂志, 2024, 24(7): 510-515.
[6]	吴桂智, 田宏. Meige综合征脑深部电刺激术治疗进展[J]. 中国现代神经疾病杂志, 2024, 24(7): 516-521.
[7]	孟凡刚, 张建国. 耳后磨骨槽技术在脑深部电刺激术中的应用[J]. 中国现代神经疾病杂志, 2024, 24(7): 522-524.
[8]	陈琳, 潘华. 功能性震颤的电生理诊断[J]. 中国现代神经疾病杂志, 2024, 24(7): 573-578.
[9]	魏俊吉, 常健博. 深入基层医院普及神经外科重症管理理念[J]. 中国现代神经疾病杂志, 2024, 24(6): 403-406.
[10]	史若琳, 高秀洁, 崔家宁, 邵妍, 谢璐霜, 刘毅. 5-羟色胺与帕金森病非运动症状研究进展[J]. 中国现代神经疾病杂志, 2024, 24(6): 497-501.
[11]	李海峰. 在进入靶向治疗的时代激素仍然是重症肌无力治疗的基础[J]. 中国现代神经疾病杂志, 2024, 24(5): 295-307.
[12]	许鸿嘉, 舒崖清, 王蘋, 李蕃, 许顺良, 邱伟, 马晓宇. 抗水通道蛋白4抗体阳性视神经脊髓炎谱系疾病诊断与治疗进展[J]. 中国现代神经疾病杂志, 2024, 24(5): 308-314.
[13]	黄瑀, 廖金池, 舒崖清. 抗N-甲基-D-天冬氨酸受体脑炎睡眠障碍研究进展[J]. 中国现代神经疾病杂志, 2024, 24(5): 315-319.
[14]	刘彩云, 金涛. 树突状细胞在多发性硬化免疫治疗中的应用[J]. 中国现代神经疾病杂志, 2024, 24(5): 320-330.
[15]	叶睿曦, 蔡林君, 孔雪莹, 李劲梅, 周东, 洪桢. 抗N-甲基-D-天冬氨酸受体脑炎急性期严重程度及短期预后影响因素分析[J]. 中国现代神经疾病杂志, 2024, 24(5): 331-339.

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

2 自身免疫性脑炎相关癫癎功能影像学研究进展

Progress in functional imaging of autoimmune encephalitis associated with epilepsy

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价