摘要：

目的 探讨缺血性脑白质疏松症病变部位（侧脑室体旁和皮质下白质）相关危险因素。方法 共 127 例缺血性脑白质疏松症患者（包括单纯侧脑室体旁白质疏松 78 例以及侧脑室体旁和皮质下白质疏松共存 49 例），行头部 MRI检查，采用 Fazekas 分级评价脑白质疏松分级，单因素和多因素前进法Logistic回归分析筛查缺血性脑白质疏松症相关危险因素。结果 Logistic回归分析显示，年龄是单纯侧脑室体旁白质疏松的危险因素（OR = 1.103，95%CI：1.054 ~ 1.155；P = 0.000）；年龄（OR = 1.154，95%CI：1.072 ~ 1.242；P = 0.000）、高血压（OR = 6.804，95%CI：1.793 ~ 25.825；P = 0.005）和凝血酶原时间（OR = 2.418，95%CI：1.025 ~ 5.704；P = 0.044）是侧脑室体旁和皮质下白质疏松的危险因素；年龄是总侧脑室体旁白质疏松的危险因素（OR = 1.137，95%CI：1.064 ~ 1.216；P = 0.000）。结论 年龄是单纯侧脑室体旁白质疏松的危险因素，年龄、高血压和凝血酶原时间是侧脑室体旁和皮质下白质疏松的危险因素；年龄是总侧脑室体旁白质疏松的危险因素。 

关键词: 脑白质疏松症, 脑缺血, 危险因素, 回归分析

Abstract:

Objective To explore the related risk factors for ischemic leukoaraiosis (periventricular lesions and subcortical lesions). Methods A total of 127 patients with ischemic leukoaraiosis, including 78 patients with periventricular leukoaraiosis and 49 patients with coexisted periventricular and subcortical leukoaraiosis, were enrolled in this study. Fazekas classification was used to rate the severity of leukoaraiosis. Univariate and multivariate forward Logistic regression analysis were used to analyze and screen the related risk factors for ischemic leukoaraiosis. Results Logistic regression analysis showed age was independent risk factor for periventricular leukoaraiosis (OR = 1.103, 95%CI: 1.054-1.155; P = 0.000); age (OR = 1.154, 95%CI: 1.072-1.242; P = 0.000), hypertension (OR = 6.804, 95%CI: 1.793-25.825; P = 0.005) and prothrombin time (PT; OR = 2.418, 95% CI: 1.025-5.704, P = 0.044) were independent risk factors for periventricular and subcortical leukoaraiosis; age was independent risk factor for total periventricular leukoaraiosis (OR = 1.137, 95% CI: 1.064-1.216; P = 0.000). Conclusions Age was independent risk factor for periventricular leukoaraiosis; age, hypertension and PT were independent risk factors for periventricular and subcortical leukoaraiosis; age was independent risk factor for total periventricular leukoaraiosis.

Key words: Leukoaraiosis, Brain ischemia, Risk factors, Regression analysis