中国现代神经疾病杂志 ›› 2023, Vol. 23 ›› Issue (9): 864-871. doi: 10.3969/j.issn.1672-6731.2023.09.016

• 综述 • 上一篇    

2 不同性别动脉粥样硬化差异性研究进展

王亚伟1, 田锋2,*()   

  1. 1. 272067 济宁医学院临床医学院2021级
    2. 272011 山东省济宁市第一人民医院神经内科
  • 收稿日期:2023-05-16 出版日期:2023-09-25 发布日期:2023-10-10
  • 通讯作者: 田锋
  • 基金资助:
    山东省医药卫生科技发展计划(202103070424)

Research progress on the difference of atherosclerosis between different sexes

Ya-wei WANG1, Feng TIAN2,*()   

  1. 1. Grade 2021, School of Clinical Medicine, Ji'ning Medical University, Ji'ning 272067, Shandong, China
    2. Department of Neurology, Ji'ning No. 1 People's Hospital, Ji'ning 272011, Shandong, China
  • Received:2023-05-16 Online:2023-09-25 Published:2023-10-10
  • Contact: Feng TIAN
  • Supported by:
    Development Plan of Medicine and Health Science and Technology in Shandong(202103070424)

摘要:

心脑血管病是病残和病死的主要原因,动脉粥样硬化是其重要病因。绝经前女性动脉粥样硬化发生率明显低于同龄男性,而绝经后女性动脉粥样硬化发生率显著升高甚至超过同龄男性,与雌激素水平密切相关。本文从影像学检查、危险因素、肠道微生物群和血管炎症反应对动脉粥样硬化影响等方面综述动脉粥样硬化的性别差异,为动脉粥样硬化的精准医疗提供依据。

关键词: 动脉粥样硬化, 性别因素, 磁共振成像, 危险因素, 胃肠道微生物组, 炎症, 综述

Abstract:

Cardiovascular and cerebrovascular diseases are the main causes of disability and death, and atherosclerosis is an important cause. The incidence of atherosclerosis in premenopausal women is significantly lower than that in men of the same age, while the incidence of atherosclerosis in postmenopausal women is significantly higher than that in men of the same age, which is closely related to estrogen levels. In this paper, sex differences in atherosclerosis were reviewed from the aspects of imaging examination, risk factors, intestinal microbiome and vascular inflammatory effects on atherosclerosis, to provide evidence for precision medical treatment of atherosclerosis.

Key words: Atherosclerosis, Sex factors, Magnetic resonance imaging, Risk factors, Gastrointestinal microbiome, Inflammation, Review