摘要：

特发性炎性脱髓鞘疾病属神经系统自身免疫性疾病，是一组包括多种亚型的谱系疾病。好发于青壮年，呈复发?缓解病程，每次发作常遗留神经系统症状与体征，最终导致神经功能障碍。早期诊断、密切监测病情和及时治疗是改善长期预后的关键。我国国民经济和社会发展第十二个五年规划（简称“十二五”）时期，中山大学附属第三医院胡学强教授研究团队在特发性炎性脱髓鞘疾病病因、发病机制、临床特点、诊断与鉴别诊断、治疗策略等方面取得成果，本文拟就上述研究成果进行简要综述。

关键词: 脱髓鞘疾病, 中国, 综述

Abstract:

Idiopathic inflammatory demyelinating diseases (IIDDs) belongs to autoimmune diseases of nervous system, which is a group of spectrum disorders including multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSDs), acute disseminated encephalomyelitis (ADEM) and other related diseases. It often occurs in young adults, and the course is relapse-remitting, often leaving neurological sequelae in each episode, and ultimately leading to nerve dysfunction. Early diagnosis, close disease monitoring and prompt treatment are the keys to improve the long-term prognosis of patients. During the period of Twelfth Five-Year Plan for National Economic and Social Development, our team devoted ourselves to the studies of IIDDs and achieved results in the etiology, pathogenesis, clinical features, diagnosis and differential diagnosis, and treatment strategies of the disease respectively. In this paper, we briefly review the above research findings.

Key words: Demyelinating diseases, China, Review