摘要：
阿尔茨海默病是一种病因和发病机制尚未明确的神经变性病，其典型病理改变为β-淀粉样蛋白沉积形成的神经炎性斑（亦称老年斑）和tau 蛋白异常聚集形成的神经原纤维缠结，常累及胆碱能系统，其中丁酰胆碱酯酶在阿尔茨海默病发病与进展过程中发挥重要作用。本文就丁酰胆碱酯酶在阿尔茨海默病发病机制中的作用进行简要综述。
关键词:
阿尔茨海默病,
丁酰胆碱酯酶,
综述
Abstract:
Alzheimer's disease (AD) is a neurodegenerative disease of unknown etiology and pathogenesis. The typical pathological changes of AD include neuritic plaques [NPs, senile plaques (SPs)] with deposition of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) due to abnormal aggregation of tau protein. Researches show that cholinergic system is related to AD, and butyrylcholinesterase (BChE) plays an important role in AD. This article reviews the important role of BChE in the pathogenesis of AD.
Key words:
吴昊, 李旭东, 彭丹涛, 焦劲松, 李延峰, 于普林, 纪勇. 丁酰胆碱酯酶在阿尔茨海默病发病机制中的作用[J]. 中国现代神经疾病杂志, 2017, 17(12): 933-936.
WU Hao, LI Xu-dong, PENG Dan-tao, JIAO Jin-song, LI Yan-feng, YU Pu-lin, JI Yong. The role of butyrylcholinesterase in the pathogenesis of Alzheimer's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2017, 17(12): 933-936.