Research progress on assessment of serum biomarkers related to senile frailty

doi:10.16352/j.issn.1001-6325.2022.04.018

Abstract

Abstract: The assessment of senile frailty still implemented with scales and questionnaires. This subjective assessment method is prone to vary greatly with the assessors and scales. Therefore, it is particularly important to explore the Objective diagnosis basis of frailty.With the continuous development of population cohort and observational studies, great progress has been made in the serology of senile frailty.This article mainly reviews the influence mechanism of serum inflammatory factors, hormones, vitamins, homocysteine and related protein molecules on frailty and provides new ideas to further exploring the Objective diagnosis basis of frailty in the elderly.

Key words: frailty, biological markers, mechanism, aged

CLC Number:

R592

DAI Jing-rong, LI Jie, HE Xu, LI Yan. Research progress on assessment of serum biomarkers related to senile frailty[J]. Basic & Clinical Medicine, 2022, 42(4): 646-650.

References

[1] Hoogendijk EO, Afilalo J, Ensrud KE, et al. Frailty: implications for clinical practice and public health[J]. Lancet,2019,394:1365-1375.
[2] Barsony J, Kleess L, Verbalis JG. Hyponatremia is linked to bone loss, osteoporosis, fragility and bone fractures[J]. Front Horm Res, 2019,52:49-60.
[3] 吴炎,边瓯,马宁,等.老年住院患者血钠水平与衰弱相关性研究[J].临床军医杂志,2020,48:149-151,154.
[4] Aranda-Gallardo M, Gonzalez-Lozano A, Oña-Gil JI, et al. Relation between hyponatraemia and falls by acute hospitalised patients: a case-control study[J]. J Clin Nurs, 2021. doi:10.1111/jocn.15952.
[5] Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis[J]. Ageing Res Rev, 2016,31:1-8.
[6] Mehta M, Louissaint J, Parikh NS, et al. Cognitive function, sarcopenia, and inflammation are strongly associated with frailty: a framingham cohort study[J]. Am J Med,2021. doi:10.1016/j.amjmed.2021.07.012.
[7] Tembo MC, Holloway-Kew KL, Bortolasci CC, et al. Association between serum interleukin-6 and frailty in older men: cross-sectional data[J]. Eur Geriatr Med, 2021,12:887-892.
[8] Hsu PF, Pan WH, Yip BS, et al. C-reactive protein predicts incidence of dementia in an elderly asian community cohort[J]. J Am Med Dir Assoc,2017,18:277.doi:10.1016/j.jamda.2016.12.006.
[9] Wimalawansa SJ, Razzaque MS, Al-Daghri NM. Calcium and vitamin D in human health: Hype or real?[J]. J Steroid Biochem Mol Biol,2018,180:4-14.
[10] 戴靖榕,李婕,何旭. 住院老年患者25-羟维生素D及白介素6与衰弱的相关性研究[J]. 中国全科医学,2021. doi:10.12114/j.issn.1007-9572.2021.02.037.
[11] Kitsu T, Kabasawa K, Ito Y, et al. Low serum 25-hydroxyvitamin D is associated with low grip strength in an older Japanese population[J]. J Bone Miner Metab, 2020,38:198-204.
[12] Remelli F, Vitali A, Zurlo A, et al . Vitamin D deficiency and sarcopenia in older persons[J]. Nutrients,2019,11:28-61. doi:10.3390/nu11122861.
[13] Haren MT, Siddiqui AM, Armbrecht HJ, et al. Testosterone modulates gene expression pathways regulating nutri-ent accumulation, glucose metabolism and protein turn-over in mouse skeletal muscle[J]. Int J Androl, 2011,34:55-68.
[14] Yeap BB, Alfonso H, Chubb SAP, et al. U-Shaped association of plasma testosterone, and no association of plasma estradiol, with incidence of fractures in men[J]. J Clin Endocrinol Metab,2020,105:dgaa115. doi:10.1210/clinem/dgaa115.
[15] Ahmed M, Shaikh A, Fida M. Diagnostic performance of various cephalometric parameters for the assessment of vertical growth pattern[J]. Dental Press J Orthod,2016,21:41-49.
[16] Ikeda K, Horie-Inoue K, Inoue S. Functions of estrogen and estrogen receptor signaling on skeletal muscle[J]. J Steroid Biochem Mol Biol,2019.doi:10.1016/j.jsbmb.2019.105375.
[17] Carcaillon L, García-García FJ, Tresguerres JA, et al. Higher levels of endogenous estradiol are associated with frailty in postmenopausal women from the toledo study for healthy aging[J]. J Clin Endocrinol Metab, 2012,97:2898-2906.
[18] Soni RM, Tiwari SC, Mahdi AA, et al. Serum homocysteine and behavioral and psychological symptoms of dementia: Is there any correlation in alzheimer's disease?[J]. Ann Neurosci, 2019,25:152-159.
[19] Ruan Y, Guo Y, Kowal P, et al. Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China[J]. BMC Geriatr,2019,19:327-340.
[20] 张佳佳,王丽.老年2型糖尿病病人糖脂代谢指标与衰弱程度的相关性研究[J]. 实用老年医学,2020,4:344-347.
[21] Zaslavsky O, Walker RL, Crane PK, et al. Glucose levels and risk of frailty[J]. Gerontol A Biol Sci Med Sci, 2016,71:1223-1229.
[22] Hamada S, Gulliford MC. Mortality in individuals aged 80 and older with type 2 diabetes mellitus in relation to glycosylated hemoglobin, blood pressure, and total cholesterol[J]. J Am Geriatr Soc, 2016,64:1425-1431.
[23] Mailliez A, Guilbaud A, Puisieux F, et al. Circulating biomarkers characterizing physical frailty: CRP, hemoglobin, albumin, 25OHD and free testosterone as best biomarkers. Results of a meta-analysis[J]. Exp Gerontol,2020. doi:10.1016/j.exger.2020.111014.
[24] Yang L, Smith L, Hamer M. Gender-specific risk factors for incident sarcopenia: 8-year follow-up of the English longitudinal study of ageing[J]. J Epidemiol Community Health, 2019,73:86-88.