Basic & Clinical Medicine ›› 2025, Vol. 45 ›› Issue (2): 253-257.doi: 10.16352/j.issn.1001-6325.2025.02.0253

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Research progress in the characterization of amino acid metabolism in frailty patients

WU Huishan1, LIAO Yingping2, LI Meng3*   

  1. 1. The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053;
    2. Eugenics and Genetic Experiment Diagnosis Center, Guangdong Province Qingyuan Maternal and Child Health Hospital, Qingyuan 511500;
    3. Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310013, China
  • Received:2024-09-02 Revised:2024-12-03 Online:2025-02-05 Published:2025-01-17
  • Contact: *lmbcwan@163.com

Abstract: Frailty is a complex aging syndrome characterized by diminished strength and physiological dysfunction. Early diagnosis of frailty is of great value in helping the elderly to improve the quality of life. However, specific biological markers to diagnose frailty are still lacking. In recent years, moderate protein intake has been shown to be an effective intervention in the management of frailty in older adults, and the relationship between frailty and amino acid metabolism has received widespread attention. This review discusses recent advances in the study of the mechanisms by which amino acid metabolism affects frailty and provide new ideas for searching specific biomarkers of frailty.

Key words: frailty, amino acid metabolism, diagnose

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