Garlic active ingredients in prevention and treatment of osteoarthritis

doi:10.16352/j.issn.1001-6325.2025.02.0249

Abstract

Abstract: Osteoarthritis(OA) is a common concern over the world. Garlic is a kind of natural herbal medicine, and its active ingredients have shown some anti-inflammatory, antioxidant, anti-catabolic, analgesic and other pharmacological effects. Garlic and its active components alleviate the inflammatory response of OA by inhibiting the expression of inflammatory factors and signal pathways such as NF-κB and PI3K/Akt. They slow down the progression of OA by inhibiting the expression of extracellular matrix (ECM) degrading enzymes. Additionally, they reduce the oxidative damage of joints by upregulating the expression of antioxidant enzymes. Moreover, the active components of garlic can relieve OA pain by activating the potassium ion pathway (Kv7), ATP-sensitive potassium channel(K-ATP), and the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1)-NAD(P)H:quinone oxidoreductase 1 (NQO1) signaling pathway.

Key words: garlic, active ingredient, prevention and treatment, osteoarthritis

CLC Number:

R969

WU Siyu, SUN Xutao, CAO Shuo, MAO Caiyun, ZHOU Qi, SONG Yunjia. Garlic active ingredients in prevention and treatment of osteoarthritis[J]. Basic & Clinical Medicine, 2025, 45(2): 249-252.

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