抗衰老 Klotho 基因在炎性反应和纤维化中的作用

doi:10.16352/j.issn.1001-6325.2025.10.1382

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (10): 1382-1386.doi: 10.16352/j.issn.1001-6325.2025.10.1382

抗衰老 Klotho 基因在炎性反应和纤维化中的作用

叶敏^1,2,4, 郭秀英^1*, 王丹心³, 何光亮^1,4,5*

1.海南科技职业大学,海南海口 571126;
2.海南医科大学,海南海口 570100;
3.海南医学院第一附属医院, 海南海口 570102;
4.合江县中医医院,四川泸州 646000;
5.西南医科大学合江医院, 四川泸州 646200

收稿日期:2024-11-14 修回日期:2025-02-26 出版日期:2025-10-05 发布日期:2025-09-22
通讯作者: ^*guoxy168567@vip.sina.com; 1245260196@qq.com
基金资助:
海南省自然科学基金(823RC580);海南省高等学校科学研究项目(Hnky2021ZD-15);海南省卫生健康科技创新联合项目(WSJK2024QN008)

Role of anti-aging Klotho gene in inflammatory responses and fibrosis

YE Min^1,2,4, GUO Xiuying^1*, WANG Danxin³, HE Guangliang^1,4,5*

1. Hainan Vocational University of Science and Technology, Haikou 571126;
2. Hainan Medical University, Haikou 570100;
3. the First Affiliated Hospital of Hainan Medical University, Haikou 570102;
4. Hejiang Traditional Chinese Medicine Hospital, Luzhou 646000;
5. Hejiang Hospital of Southwest Medical University, Luzhou 646200, China

Received:2024-11-14 Revised:2025-02-26 Online:2025-10-05 Published:2025-09-22
Contact: ^*guoxy168567@vip.sina.com; 1245260196@qq.com

摘要/Abstract

摘要： 抗衰老 Klotho 基因不仅能延缓衰老进程,还可通过影响单核细胞-巨噬细胞、T细胞、B细胞等炎性细胞来调节纤维化和炎性反应;利用成纤维细胞生长因子(FGF)及转化生长因子-β(TGF-β)、Toll 样受体(TLR)、核因子-κB(NF-κB)、肾素-血管紧张素系统(RAS)等炎性途径调控纤维化和炎性反应相关进程。因此,阐明Klotho调控炎性反应与纤维化的分子机制,并基于此开发上调Klotho水平的靶向干预策略,有望为相关疾病的防治提供新的理论依据和治疗靶点。

关键词: Klotho, 抗衰老, 炎性反应, 组织纤维化

Abstract: The anti-aging Klotho gene can not only delay the aging process but also regulate fibrosis and inflammatory responses by influencing inflammatory cells such as monocytes-macrophages, T cells, and B cells. It can regulate the processes related to fibrosis and inflammatory responses through inflammatory pathways such as fibroblast growth factor (FGF), transforming growth factor-β(TGF-β), Toll-like receptor(TLR), nuclear factor-κB(NF-κB), and the renin-angiotensin system (RAS). Thus, elucidating the molecular mechanisms by which Klotho regulates inflammatory responses and fibrosis, and developing targeted intervention strategies to upregulate Klotho levels based on these mechanisms, may provide new theoretical basis and therapeutic targets for the prevention and treatment of related diseases.

Key words: Klotho, anti-aging, inflammation, tissue fibrosis

中图分类号:

R363.1

叶敏, 郭秀英, 王丹心, 何光亮. 抗衰老 Klotho 基因在炎性反应和纤维化中的作用[J]. 基础医学与临床, 2025, 45(10): 1382-1386.

YE Min, GUO Xiuying, WANG Danxin, HE Guangliang. Role of anti-aging Klotho gene in inflammatory responses and fibrosis[J]. Basic & Clinical Medicine, 2025, 45(10): 1382-1386.

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抗衰老 Klotho 基因在炎性反应和纤维化中的作用

Role of anti-aging Klotho gene in inflammatory responses and fibrosis

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