重金属暴露对儿童支气管哮喘的影响

doi:10.16352/j.issn.1001-6325.2025.01.0121

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (1): 121-125.doi: 10.16352/j.issn.1001-6325.2025.01.0121

重金属暴露对儿童支气管哮喘的影响

王蓓蕾¹, 苏醒岳¹, 马香^1,2,3*

山东大学附属儿童医院1.呼吸科; 2.济南市儿童呼吸病重点实验室; 3.山东省儿童健康及疾病研究中心,山东济南 250022

收稿日期:2024-05-09 修回日期:2024-07-03 出版日期:2025-01-05 发布日期:2024-12-25
通讯作者: ^*maxiang0176@163.com
基金资助:
山东省医药卫生计划重点项目(202306011027);济南市临床科技创新项目(202134067,202225022);山东省自然基金(ZR2021MH147);济南市卫健委大数据项目(2022-BD-13)

Effects of heavy metal exposure on bronchial asthma in children

WANG Beilei¹, SU Xingyue¹, MA Xiang^1,2,3*

1. Department of Respiratory Disease; 2. Jinan Key Laboratory of Pediatric Respiratory Disease; 3. Shandong Children′s Health and Disease Research Center, Children′s Hospital Affiliated to Shandong University, Jinan 250022, China

Received:2024-05-09 Revised:2024-07-03 Online:2025-01-05 Published:2024-12-25
Contact: ^*maxiang0176@163.com

摘要/Abstract

摘要： 支气管哮喘(哮喘)的原因复杂、诱因众多。重金属在人类生产生活中的应用不断增加,人类暴露于重金属的机会也随之增多。本文总结了近年来的研究,重金属暴露对儿童哮喘的影响主要是通过促进活性氧(ROS)产生,诱导氧化应激,造成免疫紊乱,增加炎性因子水平,促进气道炎性反应及气道重塑,加重哮喘的发生和发展。深入研究重金属对儿童哮喘的影响及相关机制,能够为哮喘管理提供一定的指导。

关键词: 支气管哮喘, 儿童, 重金属

Abstract: Bronchial asthma(asthma) is a chronic respiratory disease with complex etiology. Because of increasing application of heavy metals in human society, human exposure to heavy metals is a challenge to public health. This review summarizes recent studies to evaluate the effects and mechanisms of heavy metal exposure on asthma in children. Results of researches have showed that heavy metal exposure resulted in production of reactive oxygen species (ROS) to induce oxidative stress, enhancement of the level of inflammatory cytokines, promoting airway inflammatory response and airway remodeling and thus aggravating the occurrence and development of asthma. Further study on these effects may lead to the development of clinical guidance for asthma management.

Key words: bronchial asthma, child, heavy metals

中图分类号:

R725.6

王蓓蕾, 苏醒岳, 马香. 重金属暴露对儿童支气管哮喘的影响[J]. 基础医学与临床, 2025, 45(1): 121-125.

WANG Beilei, SU Xingyue, MA Xiang. Effects of heavy metal exposure on bronchial asthma in children[J]. Basic & Clinical Medicine, 2025, 45(1): 121-125.

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重金属暴露对儿童支气管哮喘的影响

Effects of heavy metal exposure on bronchial asthma in children

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