线粒体融合在阿霉素诱导心脏毒性中的作用

doi:10.16352/j.issn.1001-6325.2025.01.0126

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (1): 126-129.doi: 10.16352/j.issn.1001-6325.2025.01.0126

线粒体融合在阿霉素诱导心脏毒性中的作用

王钰淇¹, 王心雨¹, 罗皓文¹, 逯照鑫¹, 赵艺玮¹, 常盼^2*

1.西安医学院第二临床医学院麻醉系,陕西西安 710038;
2.空军军医大学基础部生理与病理生理教研室,陕西西安 710000

收稿日期:2024-05-16 修回日期:2024-07-15 出版日期:2025-01-05 发布日期:2024-12-25
通讯作者: ^*herepanpan@163.com
基金资助:
陕西省科技厅项目(2024ZC-KJXX-015);陕西省教育厅服务地方专项科学研究计划(23JC059);医臻基因育才计划(2023YZ06) 西安医学院大学生创新创业训练计划(S202311840063);2023年度国家资助博士后研究人员计划C档项目(GZC20233580)

Role of mitochondrial fusion in doxorubicin-induced cardiotoxicity

WANG Yuqi¹, WANG Xinyu¹, LUO Haowen¹, LU Zhaoxin¹, ZHAO Yiwei¹, CHANG Pan^2*

1. Department of Anesthesia,Second Clinical Medical College, Xi′an Medical College, Xi′an 710038;
2. Department of Physiology and Pathophysiology, Basic Department, Air Force Medical University, Xi′an 710000, China

Received:2024-05-16 Revised:2024-07-15 Online:2025-01-05 Published:2024-12-25
Contact: ^*herepanpan@163.com

摘要/Abstract

摘要： 阿霉素是一种广泛使用的抗肿瘤药物。靶向线粒体融合蛋白/丝裂素1/2(MFN1/2)及核转录因子红系2相关因子2(NRF2)可通过PKCε/Stat3/MFN2、SIRT1/MFN2、AMPK/NRF2等信号通路,上调线粒体融合蛋白表达,促进线粒体融合,维持动力学平衡进而保障线粒体功能,起到减少心肌细胞凋亡,减轻心脏毒性的作用。了解阿霉素性心脏毒性中线粒体融合的调节作用和机制将为疾病的防治提供新策略。

关键词: 阿霉素, 线粒体融合, 心脏毒性, 丝裂素1/2(MFN1/2), 核转录因子红系2相关因子2(NRF2)

Abstract: Adriamycin is a widely used anti-tumor drug. Targeting mitochondrial fusion proteins/mitofusion 1/2(MFN1/2) and nuclear factor-erythroid 2-related factor 2(NRF2) can up-regulate the expression of mitochondrial fusion protein through PKCε/Stat3/MFN2, SIRT1/MFN2, AMPK/NRF2 and other signaling pathways, promote mitochondrial fusion, maintain kinetic balance and protect mitochondrial function, reduce myocardial cell apoptosis and reduce cardiac toxicity. Understanding the regulatory role and mechanism of mitochondrial fusion in doxorubicin-induced cardio toxicity will provide new strategies for the prevention and treatment of diseases.

Key words: doxorubicin, mitochondrial fusion, cardiotoxicity, mitofusin(MFN1/2), nuclear factor-erythroid 2-related factor 2(NRF2)

中图分类号:

R541.9

王钰淇, 王心雨, 罗皓文, 逯照鑫, 赵艺玮, 常盼. 线粒体融合在阿霉素诱导心脏毒性中的作用[J]. 基础医学与临床, 2025, 45(1): 126-129.

WANG Yuqi, WANG Xinyu, LUO Haowen, LU Zhaoxin, ZHAO Yiwei, CHANG Pan. Role of mitochondrial fusion in doxorubicin-induced cardiotoxicity[J]. Basic & Clinical Medicine, 2025, 45(1): 126-129.

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线粒体融合在阿霉素诱导心脏毒性中的作用

Role of mitochondrial fusion in doxorubicin-induced cardiotoxicity

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