鉴别肺孢子菌感染与定植的研究进展

doi:10.16352/j.issn.1001-6325.2025.01.0116

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (1): 116-120.doi: 10.16352/j.issn.1001-6325.2025.01.0116

鉴别肺孢子菌感染与定植的研究进展

李星辰, 童瑾^*

重庆医科大学附属第二医院呼吸与危重症医学科, 重庆 400072

收稿日期:2023-11-22 修回日期:2024-06-04 出版日期:2025-01-05 发布日期:2024-12-25
通讯作者: ^*tongjin01234@163.com
基金资助:
2022年度重庆市卫生适宜技术推广项目(2022jstg021)

Progress of researches on the differential diagnosis of Pneumocystis jiroveci infection and colonization

LI Xingchen, TONG Jin^*

Department of Respiratory,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400072,China

Received:2023-11-22 Revised:2024-06-04 Online:2025-01-05 Published:2024-12-25
Contact: ^*tongjin01234@163.com

摘要/Abstract

摘要： 耶氏肺孢子菌(PJ)是一种非典型的条件致病性真菌,PJ定植是肺孢子菌肺炎(PJP)的潜在危险因素,积极鉴别PJ定植或感染有利于合理指导抗生素使用。血清G试验结合分子检测技术、外周血 CD4⁺T水平以及通过转录组测序技术对滋养体和包囊独立表征等方法在鉴别PJ定植与感染上虽有获益,但尚未建立统一标准。本文立足于PJ病原学、致病机制、PJP 临床特征及诊断方法,通过阐述鉴别PJ感染与定植的进展,为临床诊疗提供更为客观全面的鉴别思路。

关键词: 耶氏肺孢子菌, 肺孢子菌肺炎, 定植, 诊断, 鉴别诊断

Abstract: Pneumocystis jiroveci(PJ) is an atypical conditional pathogenic fungus. PJ colonization is a potential risk factor for Pneumocystis jiroveci pneumonia (PJP). Active identification of PJ colonization or infection is conducive to rational use of antibiotics. Although serum G test combined with molecular detection technology, peripheral blood CD4⁺ T level and independent characterization of trophozoites and cysts by transcriptome sequencing technology may support identifying PJ colonization and diagnosis of infection, unified standards have not yet been established. Based on the pathogenic characteristics and pathogenic mechanism of PJ,clinical characteristics and diagnostic methods of PJP, this paper reviews the progress of differential diagnosis of PJ infection and colonization, so as to provide more objective and comprehensive differential strategy for clinical diagnosis and treatment.

Key words: Pneumocystis jroveci, Pneumocystis jroveci pneumonia, colonization, diagnosis, differential diagnosis

中图分类号:

R563.1

李星辰, 童瑾. 鉴别肺孢子菌感染与定植的研究进展[J]. 基础医学与临床, 2025, 45(1): 116-120.

LI Xingchen, TONG Jin. Progress of researches on the differential diagnosis of Pneumocystis jiroveci infection and colonization[J]. Basic & Clinical Medicine, 2025, 45(1): 116-120.

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鉴别肺孢子菌感染与定植的研究进展

Progress of researches on the differential diagnosis of Pneumocystis jiroveci infection and colonization

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