Piezo1在红细胞形态及功能调控中的作用

doi:10.16352/j.issn.1001-6325.2024.12.1702

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (12): 1702-1706.doi: 10.16352/j.issn.1001-6325.2024.12.1702

Piezo1在红细胞形态及功能调控中的作用

陈百鑫, 李越, 曲音音, 李正迁, 郭向阳^*

北京大学第三医院麻醉科,北京 100191

收稿日期:2024-03-26 修回日期:2024-06-03 出版日期:2024-12-05 发布日期:2024-11-26
通讯作者: ^*puthmzk@hsc.pku.edu.cn
基金资助:
国家自然科学基金面上项目(82271222);北京大学第三医院临床重点项目(BYSYZD2019027)

The role of Piezo1 in the regulation of erythrocyte morphology and function

CHEN Baixin, LI Yue, QU Yinyin, LI Zhengqian, GUO Xiangyang^*

Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China

Received:2024-03-26 Revised:2024-06-03 Online:2024-12-05 Published:2024-11-26
Contact: ^*puthmzk@hsc.pku.edu.cn

摘要/Abstract

摘要： Piezo1是一种机械敏感离子通道蛋白质,在哺乳动物细胞中广泛表达,能够感知机械力刺激并介导信号的转导。血液的主要细胞成分红细胞的细胞膜上也镶嵌有Piezo1。Piezo1通过介导Ca²⁺流入细胞与Gardos通道 (KCa3.1)形成串联,构成“Piezo1-Ca²⁺-Gardos通道轴”来调节红细胞的形态及功能。但是当Piezo1表达异常或被特异性激动剂(Yoda1)过度激活后,也会导致红细胞形态异常及功能障碍,甚至引起相关遗传性疾病的发生。

关键词: 红细胞, Piezo1, 离子通道, 疾病

Abstract: Piezo1 is a mechanosensitive ion channel protein widely expressed in mammalian cells with the function of sensing mechanical stimuli and of mediating signaling, and is embedded in the membranes of erythrocytes, the major cellular component of blood.Piezo1 regulates the morphology and function of erythrocytes by mediating the influx of Ca²⁺ into the cell in crosstalk with the Gardos channel (KCa3.1), constituting the “Piezo1-Ca²⁺-Gardos channel axis”. However, when Piezo1 is abnormally expressed or over-activated by its specific agonist (Yoda1), it can also lead to abnormal erythrocyte morphology and dysfunction, and even cause the development of related hereditary diseases.

Key words: erythrocyte, Piezo1, ion channels, disease

中图分类号:

R331.1+41

陈百鑫, 李越, 曲音音, 李正迁, 郭向阳. Piezo1在红细胞形态及功能调控中的作用[J]. 基础医学与临床, 2024, 44(12): 1702-1706.

CHEN Baixin, LI Yue, QU Yinyin, LI Zhengqian, GUO Xiangyang. The role of Piezo1 in the regulation of erythrocyte morphology and function[J]. Basic & Clinical Medicine, 2024, 44(12): 1702-1706.

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Piezo1在红细胞形态及功能调控中的作用

The role of Piezo1 in the regulation of erythrocyte morphology and function

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