PTTG1在肿瘤发病机制中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.09.1448

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (9): 1448-1452.doi: 10.16352/j.issn.1001-6325.2023.09.1448

PTTG1在肿瘤发病机制中作用的研究进展

吴念平^1,2, 黄惠利^1,2, 周快乐³, 周策凡^1,2*, 唐景峰^1,2*

湖北工业大学 1.生物工程与食品学院生物医药研究院生物医药系;2.国家细胞调控与分子药物“111”引智基地,湖北武汉 430068;
3.江西贵溪市人民医院外一科,江西贵溪 335400

收稿日期:2022-10-26 修回日期:2023-02-22 出版日期:2023-09-05 发布日期:2023-09-01
通讯作者: ^*cefan@whu.edu.cn; tangjingfeng@hbut.edu.cn
基金资助:
国家自然科学基金(31871176, 32070726)

Advances on the role of PTTG1 in the pathogenesis of tumors

WU Nianping^1,2, HUANG Huili^1,2, ZHOU Kuaile³, ZHOU Cefan^1,2*, TANG Jingfeng^1,2*

1. Department of Biomedical Sciencese, Institute of Biomedical Research School of Biological Engineering and Food; 2. National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068;
3. Department of Surgery, Guixi People's Hospital, Guixi 335400, China

Received:2022-10-26 Revised:2023-02-22 Online:2023-09-05 Published:2023-09-01
Contact: ^*cefan@whu.edu.cn; tangjingfeng@hbut.edu.cn

摘要/Abstract

摘要： 垂体肿瘤转化基因1(PTTG1)是一种从垂体中分离出来的癌基因。它能结合并抑制分离酶从而影响姐妹染色单体分离导致染色体非整倍体,激活 DNA 损伤反应途径诱导 p53依赖性衰老,还能反式激活一些癌基因进而促进细胞转化与裸鼠成瘤能力。它还能通过影响Wnt/β-catenin、上皮细胞-间充质转化(EMT)、TGFβ/SMAD3通路来促进肿瘤的生长与侵袭。本文为以PTTG1为靶点开发肿瘤治疗药物提供思路。

关键词: 垂体肿瘤转化基因1(PTTG1), 机制, 肿瘤

Abstract: Pituitary tumor transforming gene 1(PTTG1) is an oncogene which isolated from the pituitary gland. PTTG1 was previously reported to bind and inhibit separase to affect sister chromatid separation and lead to chromosome aneuploidy, activate the DNA damage response pathway to induce p53-dependent senescence, and also transactivate some oncogenes and promote cell transformation and tumorigenesis in nude mice. It can also promote tumor growth and invasion by affecting Wnt/β-catenin, epithelial-mesenchymal transition(EMT), and TGFβ/SMAD3 pathways. This article provides ideas for the development of tumor therapeutic drugs targeting PTTG1.

Key words: pituitary tumor transforming gene 1(PTTG1), mechanism, tumor

中图分类号:

:R73

吴念平, 黄惠利, 周快乐, 周策凡, 唐景峰. PTTG1在肿瘤发病机制中作用的研究进展[J]. 基础医学与临床, 2023, 43(9): 1448-1452.

WU Nianping, HUANG Huili, ZHOU Kuaile, ZHOU Cefan, TANG Jingfeng. Advances on the role of PTTG1 in the pathogenesis of tumors[J]. Basic & Clinical Medicine, 2023, 43(9): 1448-1452.

参考文献 25

[1]	Yu J, Raia P, Ghent CM, et al. Structural basis of human separase regulation by securin and cdk1-cyclin b1[J]. Nature, 2021, 596: 138-142.
[2]	Perramon M, Carvajal S, Reichenbach V, et al. The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis[J]. Liver Int, 2022, 42: 651-662.
[3]	Perramon M, Jimenez W. Pituitary tumor-transforming gene 1/delta like non-canonical notch ligand 1 signaling in chronic liver diseases[J]. Int J Mol Sci, 2022, 23. doi:10.3390/ijms23136897.
[4]	Lin X, Yang Y, Guo Y, et al. PTTG1 is involved in tnf-alpha-related hepatocellular carcinoma via the induction of c-myc[J]. Cancer Med, 2019, 8: 5702-5715.
[5]	Yang G, Xiog Y, Wang G, et al. miR-374c-5p regulates PTTG1 and inhibits cell growth and metastasis in hepatocellular carcinoma by regulating epithelial-mesenchymal transition[J]. Mol Med Rep, 2022, 25. doi:10.3892/mmr.2022.12664.
[6]	Huang S, Liao Q, Li W, et al. The lncRNA PTTG3p promotes the progression of crpc via upregulating PTTG1[J]. Bull Cancer, 2021, 108: 359-368.
[7]	Zhang Z, Jin B, Jin Y, et al. PTTG1, a novel androgen responsive gene is required for androgen-induced prostate cancer cell growth and invasion[J]. Exp Cell Res, 2017, 350: 1-8.
[8]	Huang S, Liao Q, Li L, et al. PTTG1 inhibits smad3 in prostate cancer cells to promote their proliferation[J]. Tumour Biol, 2014, 35: 6265-6270.
[9]	Cui L, Ren T, Zhao H, et al. Suppression of PTTG1 inhibits cell angiogenesis, migration and invasion in glioma cells[J]. Med Oncol, 2020, 37: 73. doi:10.1007/s12032-020-01398-2.
[10]	Cui L, Xu L, Wang G, et al. Stat3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells[J]. Oncol Lett, 2020, 20: 6. doi:10.3892/ol.2020.11867.
[11]	Zheng Y, Guo J, Zhou J, et al. Foxm1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion[J]. BMC Med Genomics, 2015, 8: 49. doi:10.1186/s12920-015-0126-9.
[12]	刘军, 齐秀恒, 武振明, 等. 垂体肿瘤转化基因调控结直肠癌细胞凋亡及其与PI3K/AKT信号通路的关系[J]. 广西医科大学学报, 2020, 37: 2173-2179.
[13]	Qiu M, Li G, Wang P, et al. Aarf domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through adck5-sox9-PTTG1 pathway[J]. Exp Cell Res, 2020, 392: 112002. doi:10.1016/j.yexcr.2020.112002.
[14]	Chen Z, Cao K, Hou Y, et al. PTTG1 knockdown enhances radiation-induced antitumour immunity in lung adenocarcinoma[J]. Life Sci, 2021, 277: 119594. doi:10.1016/j.lfs.2021.119594.
[15]	Wang W, Cao R, Su W, et al. miR-655-3p inhibits cell migration and invasion by targeting pituitary tumor-transforming 1 in non-small cell lung cancer[J]. Biosci Biotechnol Biochem, 2019, 83: 1703-1708.
[16]	Teveroni E, Di Nicuolo F, Vergani E, et al. PTTG1/zeb1 axis regulates e-cadherin expression in human seminoma[J]. Cancers (Basel), 2022, 14. doi:10.3390/cancers14194876.
[17]	Teveroni E, Di Nicuolo F, Bianchetti G, et al. Nuclear localization of PTTG1 promotes migration and invasion of seminoma tumor through activation of mmp-2[J]. Cancers (Basel), 2021, 13. doi:10.3390/cancers13020212.
[18]	Lee SS, Choi JH, Lim SM, et al. Alteration of pituitary tumor transforming gene 1 by microRNA-186 and 655 regulates invasion ability of human oral squamous cell carcinoma[J]. Int J Mol Sci, 2021, 22. doi:10.3390/ijms22031021.
[19]	Chen SW, Zhou HF, Zhang HJ, et al. The clinical significance and potential molecular mechanism of PTTG1 in esophageal squamous cell carcinoma[J]. Front Genet, 2020, 11: 583085. doi:10.3389/fgene.2020.583085.
[20]	Li JD, Farah AA, Huang ZG, et al. Clinical significance and potential regulatory mechanism of overexpression of pituitary tumor-transforming gene transcription factor in bladder cancer[J]. BMC Cancer, 2022, 22: 713. doi:10.1186/s12885-022-09810-y.
[21]	Zhou M, Chen J, Zhang H, et al. Klf10 inhibits cell growth by regulating PTTG1 in multiple myeloma under the regulation of microrna-106b-5p[J]. Int J Biol Sci, 2020, 16: 2063-2071.
[22]	Hu ZG, Zheng CW, Su HZ, et al. MicroRNA-329-mediated PTTG1 downregulation inactivates the mapk signaling pathway to suppress cell proliferation and tumor growth in cholangiocarcinoma[J]. J Cell Biochem, 2019, 120: 9964-9978.
[23]	Hu X, Yang F, Mei H. Pituitary tumor transforming gene 1 promotes proliferation and malignant phenotype in osteosarcoma via NF-KappaB signaling[J]. J Orthop Sci, 2022. doi:10.1016/j.jos.2022.10.020.
[24]	Yin L, He Z, Yi B, et al. Simvastatin suppresses human breast cancer cell invasion by decreasing the expression of pituitary tumor-transforming gene 1[J]. Front Pharmacol, 2020, 11: 574068. doi:10.3389/fphar.2020.574068.
[25]	Guo D, Gu Y, Ma D, et al. A novel microRNA miR-MTCO3P38 inhibits malignant progression via STAT3/PTTG1/MYC in hepatocellular carcinoma[J]. Genes Dis, 2022, 9: 845-848.

PTTG1在肿瘤发病机制中作用的研究进展

Advances on the role of PTTG1 in the pathogenesis of tumors

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