硫化氢在哮喘中的作用

doi:10.16352/j.issn.1001-6325.2025.09.1239

摘要/Abstract

摘要： 哮喘是慢性呼吸系统中最常见的疾病之一,病因复杂,涉及多种类型的炎性细胞和多种信号分子介质。硫化氢(H₂S)是哺乳动物体内的一种内源性气体递质,广泛参与细胞功能,参与包括呼吸系统疾病在内的多种疾病的生理病理过程,H₂S通过多种途径参与哮喘的发生发展。当H₂S生成酶水平下降,内源性H₂S水平的浓缩,可能引发哮喘发作,起到促炎作用;另一方面,H₂S启动肺诱导型一氧化氮合酶(iNOS)激活,限制了气道重塑,起到抗重塑和抗炎介质的作用。并且H₂S水平在哮喘发病的不同阶段具有差异性,哮喘患者中H₂S水平,可作为哮喘的气道炎性标志物,为哮喘的诊断提供临床证据。

关键词: 硫化氢, 哮喘, 作用机制, 生物标志物

Abstract: Asthma is one of the most common diseases in chronic respiratory system; the etiology is complex, involving many types of inflammatory cells and a variety of signaling molecular mediators. Hydrogen sulfide (H₂S) is an endogenous gas transmitter in mammals, which is widely involved in cell functions and physiological and pathological processes of various diseases, including respiratory diseases. H₂S is involved in the occurrence and development of asthma through various ways. When the H₂S-producing enzyme level decreases, the concentration of endogenous H₂S level may trigger asthma attack and play a pro-inflammatory role. On the other hand, H₂S initiates pulmonary inducible nitric oxide synthase (iNOS) activation, limiting airway remodeling, and acts as an anti-remodeling and anti-inflammatory mediator. Moreover, H₂S level varies at different stages of asthma. H₂S level in patients with asthma is a potential bio-markers of airway inflammation in asthma case and my support clinical diagnosis of asthma.

Key words: hydrogen sulfide, asthma, mechanism of action, biomarker

中图分类号:

R563
R446

崔欣月, 韩沙沙. 硫化氢在哮喘中的作用[J]. 基础医学与临床, 2025, 45(9): 1239-1242.

CUI Xinyue, HAN Shasha. Role of hydrogen sulfide in asthma[J]. Basic & Clinical Medicine, 2025, 45(9): 1239-1242.

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