TMEM基因家族在肿瘤发生发展中的作用

doi:10.16352/j.issn.1001-6325.2025.09.1243

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (9): 1243-1247.doi: 10.16352/j.issn.1001-6325.2025.09.1243

TMEM基因家族在肿瘤发生发展中的作用

凌彩霞^1,3, 王春芳², 罗艳红^1,3*

右江民族医学院 1.医学检验学院; 3.生物医药与大健康现代产业学院,广西百色 533000;
2.右江民族医学院附属医院检验科,广西百色,533000

收稿日期:2024-10-29 修回日期:2024-12-31 发布日期:2025-08-27
通讯作者: ^*lyhmail2005@126.com
基金资助:
国家自然科学基金(81960303);广西高校中青年教师科研基础能力提升项目(2024KY0555)

TMEM gene family in tumor development

LING Caixia¹, WANG Chunfang², LUO Yanhong^1,3*

1. College of Medical Laboratory Science; 3. College of Biology, Youjiang Medical University for Nationalities, Baise 533000;
2. Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000, China

Received:2024-10-29 Revised:2024-12-31 Published:2025-08-27
Contact: ^*lyhmail2005@126.com

摘要/Abstract

摘要： 跨膜蛋白基因家族(TMEM)指一类编码跨膜蛋白质的基因家族。TMEM 基因家族是通过影响血管生成的主要信号通路,影响肿瘤细胞和血管内皮细胞之间的相互作用,调控VEGF及其受体VEGFR 的表达或功能,从而影响肿瘤的血管生成。此外,TMEM 基因家族调控组蛋白翻译后修饰等机制影响肿瘤的发生发展,TMEM 蛋白翻译后修饰形式包括磷酸化、糖基化、乙酰化、棕榈酰化等。对TMEM基因家族在肿瘤发生发展中作用的机制研究帮助人们确定更加精准的靶向治疗策略。

关键词: TMEM, 肿瘤, 血管形成, 组蛋白翻译后修饰

Abstract: The transmembrane protein gene family (TMEM) refers to a group of genes that encode trans-membrane proteins. The TMEM family influences tumor angiogenesis by affecting key signaling pathways involved in angiogenesis, modulating the interactions between tumor cells and endothelial cells and regulating the expression or function of VEGF and its receptor VEGFR. Thereby it may have impact on tumor blood vessel formation. Additionally, the TMEM family regulates mechanisms such as post-translational modifications of histone, which also play a role in tumor initiation and progression. Post-translational modifications of TMEM proteins including phosphorylation, glycosylation, acetylation and palmitoylation. TMEM family contributes to tumorigenesis and may identify some novo targets used in precise medical treatment.

Key words: TMEM, tumor, angiogenesis, post-translational modification of histone

中图分类号:

凌彩霞, 王春芳, 罗艳红. TMEM基因家族在肿瘤发生发展中的作用[J]. 基础医学与临床, 2025, 45(9): 1243-1247.

LING Caixia, WANG Chunfang, LUO Yanhong. TMEM gene family in tumor development[J]. Basic & Clinical Medicine, 2025, 45(9): 1243-1247.

参考文献

[1] 王子豪, 夏小超, 李舜. 跨膜蛋白质在恶性肿瘤中作用的研究进展[J]. 基础医学与临床, 2024, 44: 398-402.
[2] Zhang P, Yan X, Zhang X, et al. TMEM215 prevents endothelial cell apoptosis in vessel regression by blunting bik-regulated er-to-mitochondrial ca influx[J]. Circ Res, 2023, 133: 739-757.
[3] Ma K, Liu S, Liang H, et al. Ca (2+)-activated Cl (-) channel TMEM16A inhibition by cholesterol promotes angiogenesis in endothelial cells[J]. J Adv Res,2021, 29: 23-32.
[4] Shan KZ, Le T, Liang P, et al. Endothelial TMEM16F lipid scramblase regulates angiogenesis[J]. bioRxiv, 2023. 137: jcs261566. doi:10.1242/jcs.261566.
[5] Zheng Y, Zhao Y, Jiang J, et al. Transmembrane protein 100 inhibits the progression of colorectal cancer by promoting the ubiquitin/proteasome degradation of HIF-1α[J]. Front Oncol, 2022, 12: 899385. doi:10.3389/fonc.2022.899385.
[6] Zhang Y, Kong Y, Guo H, et al. Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex[J]. J Mol Cell Biol, 2022, 14: mjac017. doi:10.1093/jmcb/mjac017.
[7] Field CJ, Perez AM, Samet T, et al. Involvement of transmembrane protein 184a during angiogenesis in zebrafish embryos[J]. Front Physiol, 2022, 13: 845407. doi:10.3389/fphys.2022.845407.
[8] Hu C, Zhang R, Jiang D. TMEM16A as a potential biomarker in the diagnosis and prognosis of lung cancer[J]. Arch Iran Med, 2019, 22: 32-38.
[9] Zhang X, He Y, Jiang Y, et al. TMEM229A suppresses non-small cell lung cancer progression via inactivating the ERK pathway[J]. Oncol Rep, 2021, 46:176. doi:10.3892/or.2021.8127.
[10] Zhu H, Su Z, Ning J, et al. Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer[J]. Cell Death Dis,2021, 12: 912. doi:10.1038/s41419-021-04211-8.
[11] Zhang Y, Kuang S, Qin H, et al. Multiomics analysis of TMEM200A as a pan-cancer biomarker[J]. J Vis Exp, 2023,15: 199. doi:10.3791/65795.
[12] Murali P, Johnson B P, Lu Z, et al. Novel role for the golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma[J]. Oncotarget, 2020, 11: 2747-2762.
[13] Durin Z, Houdou M, Morelle W, et al. Differential effects of d-galactose supplementation on golgi glycosylation defects in TMEM165 deficiency[J]. Front Cell Dev Biol, 2022, 10: 903953. doi:10.3389/fcell.2022.903953.
[14] Fang Y, Abuduxikuer K, Wang YZ, et al. TMEM199-congenital disorder of glycosylation with novel phenotype and genotype in a chinese boy[J]. Front Genet,2022, 13: 833495. doi:10.3389/fgene.2022.833495.
[15] Zaum AK, Kolokotronis K, Kress W, et al. A new case expanding the mutation and phenotype spectrum of TMEM5-related alpha-dystroglycanopathy[J]. Neuromuscul Disord, 2018, 28: 671-674.
[16] Wang Y, Ha M, Li M, et al. Histone deacetylase 6-mediated downregulation of TMEM100 expedites the development and progression of non-small cell lung cancer[J]. Hum Cell, 2022, 35: 271-285.
[17] Wang L, Liu X. TMEM120A-mediated regulation of chemotherapy sensitivity in colorectal cancer cells[J]. Cancer Chemother Pharmacol, 2024, 93: 11-22.
[18] Zhang Y, Qin Z, Sun W, et al. Function of protein s-palmitoylation in immunity and immune-related diseases[J]. Front Immunol, 2021, 12: 661202. doi:10.3389/fimmu.2021.661202.
[19] Dennis K, Heather LC. Post-translational palmitoylation of metabolic proteins[J]. Front Physiol,2023, 14: 1122895. doi:10.3389/fphys.2023.1122895.
[20] Rudnik S, Heybrock S, Saftig P, et al. S-palmitoylation determines TMEM55B-dependent positioning of lysosomes[J]. J Cell Sci, 2022, 135: jcs258566. doi:10.1242/jcs.258566.
[21] Ng KT, Yeung OW, Liu J, et al. Clinical significance and functional role of transmembrane protein 47 (TMEM47) in chemoresistance of hepatocellular carcinoma[J]. Int J Oncol, 2020, 57: 956-966.
[22] Liu L, Zhang J, Li S, et al. Silencing of TMEM158 inhibits tumorigenesis and multidrug resistance in colorectal cancer[J]. Nutr Cancer, 2020, 72: 662-671.
[23] Guo S, Qiu L, Chen Y, et al. TMEM16A-inhibitor loaded pH-responsive nanoparticles: a novel dual-targeting antitumor therapy for lung adenocarcinoma[J]. Biochem Pharmacol, 2020, 178: 114062. doi:10.1016/j.bcp.2020.114062.
[24] Zhang S, Wan X, Lv M, et al. TMEM92 acts as an immune-resistance and prognostic marker in pancreatic cancer from the perspective of predictive, preventive, and personalized medicine[J]. EPMA J,2022, 13: 519-534.

TMEM基因家族在肿瘤发生发展中的作用

TMEM gene family in tumor development

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	周慧聪, 邵亚娟. 老年肿瘤微环境对免疫检查点抑制剂治疗的影响[J]. 基础医学与临床, 2025, 45(9): 1139-1143.
[2]	王秋梅, 李孝远, 康琳, 孙晓红, 李海龙, 段艳平, 刘颖, 管梅, 赵林. 北京协和医院老年肿瘤患者综合评估的共识建议[J]. 基础医学与临床, 2025, 45(9): 1122-1131.
[3]	龙丽娟, 宋松泽, 叶棋浓, 蔺静. LSD1调控肿瘤免疫机制的研究进展[J]. 基础医学与临床, 2025, 45(8): 1088-1092.
[4]	秦怡, 王晓燕. 蛋白酪氨酸激酶-2在妇科肿瘤中的作用[J]. 基础医学与临床, 2025, 45(8): 1098-1102.
[5]	罗浩君, 孔德欣, 黄薇, 杨楠, 刘雁勇. 基于Hsp90的荧光分子探针的构建与胰腺肿瘤识别效应评价[J]. 基础医学与临床, 2025, 45(7): 905-911.
[6]	王大亚, 李志家, 赵德威, 陈熙猛. MMSN@Gem的构建及其抑制人膀胱癌细胞系BIU-87增殖和促凋亡[J]. 基础医学与临床, 2025, 45(6): 777-785.
[7]	郭安静, 陈翀, 罗云萍. PRTN3调控巨噬细胞表型及其抗肿瘤作用的初步研究[J]. 基础医学与临床, 2025, 45(6): 701-708.
[8]	史立洲, 韩玮, 沈晓军. 核多聚腺苷酸结合蛋白1在肿瘤中的作用[J]. 基础医学与临床, 2025, 45(6): 822-828.
[9]	曹金金, 杜娟, 瞿姗娜, 朱明宇, 汪洋, 胡翰, 刘滨磊. 多靶点CAR-T细胞疗法在急性B淋巴细胞白血病中的应用[J]. 基础医学与临床, 2025, 45(5): 675-680.
[10]	李云帆, 邹佳铭, 王钰铖, 鞠瑞, 郭磊. CTO抑制小鼠胶质瘤细胞原位生长并调节相关小胶质细胞代谢及炎性表型[J]. 基础医学与临床, 2025, 45(4): 478-485.
[11]	王丽宁, 刘红刚. 鼻腔鼻窦恶性黑色素瘤临床病理特征及其与肿瘤浸润淋巴细胞亚群的相关性[J]. 基础医学与临床, 2025, 45(4): 527-531.
[12]	张大坤, 张洪波, 董德鑫, 高翔, 孟强, 高纪元. 肾脏上皮样血管平滑肌脂肪瘤临床特点[J]. 基础医学与临床, 2025, 45(3): 375-377.
[13]	楼海均, 孟·孟根, 张振宇, 童卓云, 乌都木丽. 跨膜蛋白33在肿瘤发生发展中的作用[J]. 基础医学与临床, 2025, 45(2): 258-262.
[14]	罗钰蓓, 黄建军, 杨文秀, 张军红, 李静, 赵春华, 豆晓伟. 4株患者原代细胞源的乳腺癌细胞系建立及初步研究[J]. 基础医学与临床, 2025, 45(2): 183-188.
[15]	楼海均, 童卓云, 张振宇, 阿合叶尔克·马合沙提, 孟·孟根, 乌都木丽. 敲低DRAM2抑制肺癌细胞系A549的增殖和迁移[J]. 基础医学与临床, 2025, 45(2): 197-202.