[1] Singh G, Sander JW. The global burden of epilepsy report: implications for low- and middle-income countries[J]. Epilepsy Behav, 2020, 105: 106949. doi: 10.1016/j.yebeh.2020.106949. [2] Bloom GS. Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis[J]. JAMA Neurol, 2014, 71: 505-508. [3] Amatniek JC, Hauser WA, DelCastillo-Castaneda C, et al. Incidence and predictors of seizures in patients with Alzheimer′s disease[J]. Epilepsia, 2006, 47: 867-872. [4] Vossel KA, Beagle AJ, Rabinovici GD, et al. Seizures and epileptiform activity in the early stages of Alzheimer disease[J]. JAMA Neurol, 2013, 70: 1158-1166. [5] Sen A, Capelli V, Husain M. Cognition and dementia in older patients with epilepsy[J]. Brain, 2018, 141: 1592-1608. [6] Lau SF, Cao H, Fu AKY, et al. Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer′s disease[J]. Proc Natl Acad Sci U S A, 2020, 117: 25800-25809. [7] Chen ZP, Wang S, Zhao X, et al. Lipid-accumulated reactive astrocytes promote disease progression in epilepsy [J]. Nat Neurosci, 2023, 26: 542-554. [8] Townsend SE, Westfall JJ, Navarro JB, et al. Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue[J]. Sci Rep, 2023, 13: 527. doi: 10.1038/s41598-023-27700-6. [9] Wu J, Zhu S, Zhao C, et al. A comprehensive investigation of molecular signatures and pathways linking Alzheimer′s disease and epilepsy via bioinformatic approaches[J]. Curr Alzheimer Res, 2022, 19: 146-160. [10] Eteleeb AM, Alves SS, Buss S, et al. Transcriptomic analyses of human brains with Alzheimer′s disease identified dysregulated epilepsy-causing genes[J]. medRxiv, 2025. doi:10.1101/2025.01.01.123456. [11] Fang Y, Si X, Wang J, et al. Alzheimer disease and epilepsy: a mendelian randomization study[J]. Neurology, 2023, 101: e399-e409. [12] Kageyama R, Ohtsuka T. The Notch-Hes pathway in mammalian neural development[J]. Cell Res, 1999, 9: 179-188. [13] Lara Aparicio SY, Laureani Fierro ÁJ, Aranda Abreu GE, et al. Current opinion on the use of c-Fos in neuroscience[J]. NeuroSci, 2022, 3: 687-702. |