炎性反应在糖尿病神经病变发生中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.04.0669

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (4): 669-673.doi: 10.16352/j.issn.1001-6325.2023.04.0669

炎性反应在糖尿病神经病变发生中作用的研究进展

蒋烨, 余卓颖^*, 李民^*

北京大学第三医院麻醉科,北京 100191

收稿日期:2022-06-23 修回日期:2022-12-26 出版日期:2023-04-05 发布日期:2023-04-03
通讯作者: ^*yingyiqing@126.com; liminanesth@bjmu.edu.cn
基金资助:
国家自然科学基金(82071411,82001329)

Research progress on inflammatory mechanism of diabetic neuropathy

JIANG Ye, YU Zhuoying^*, LI Min^*

Department of Anesthesiology,Peking University Third Hospital,Beijing 100191,China

Received:2022-06-23 Revised:2022-12-26 Online:2023-04-05 Published:2023-04-03
Contact: ^*yingyiqing@126.com; liminanesth@bjmu.edu.cn

摘要/Abstract

摘要： 糖尿病神经病变(DN)是糖尿病常见的并发症,目前机制尚不明确。近年来研究表明炎性反应在DN的发生中起重要作用。在糖尿病慢性低度炎性状态下,神经元及其周围细胞中的炎性信号通路被激活,与释放出的炎性因子相互作用,促进DN的发生。深入阐明DN的炎性反应机制,将有助于寻找新的治疗靶点。

关键词: 糖尿病神经病变, 炎性反应

Abstract: Diabetic neuropathy is a common complication of diabetes, but the mechanism remains unclear. Recent studies have shown that inflammation may play a critical role in the development and progression of diabetic neuropathy. In the chronic low-grade inflammatory state of diabetes, the inflammatory signaling pathways in neurons and their surrounding cells are activated and interact with the released inflammatory factors to promote the occurrence of diabetic neuropathy. Advances in the understanding of inflammatory mechanism will facilitate the discovery of the potential therapeutic targets for the development of diabetic neuropathy.

Key words: diabetic neuropathy, inflammation

中图分类号:

R587.2

蒋烨, 余卓颖, 李民. 炎性反应在糖尿病神经病变发生中作用的研究进展[J]. 基础医学与临床, 2023, 43(4): 669-673.

JIANG Ye, YU Zhuoying, LI Min. Research progress on inflammatory mechanism of diabetic neuropathy[J]. Basic & Clinical Medicine, 2023, 43(4): 669-673.

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炎性反应在糖尿病神经病变发生中作用的研究进展

Research progress on inflammatory mechanism of diabetic neuropathy

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