关键词: 阿尔茨海默病, 运动, 自噬, 神经营养因子

Abstract: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory impairment as the main clinical manifestation. In the current situation of clinical medicine cannot be cured, the positive effect by exercise intervention brings guides the new direction of treatment. It has been found that exercise either accelerates the beta amyloid, tau protein elimination, or diminishes their production by inhibiting the mTOR signaling pathway, stimulation of endoplasmic reticulum stress, accelerated mitochondrial damage and other regulatory mechanisms of autophagy. At the same time, exercise also plays a role in regulating the apoptosis of neurons. It improves the neurotrophic factors such as BDNF and NGF, activates the pathway of PI3-k/Akt and inhibits the activity of apoptosis factors such as caspase-3 and COX-2, thus slows down neuronal apoptosis and slows down the progression of AD.

Key words: Alzheimer’s disease, exercise, autophagy, neurotrophic factors