运动对青少年肝脏功能及大小的影响

doi:10.16352/j.issn.1001-6325.2025.04.0517

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (4): 517-521.doi: 10.16352/j.issn.1001-6325.2025.04.0517

运动对青少年肝脏功能及大小的影响

张沥元^1#, 郭晓湲^1#, 杜函泽¹, 陈适¹, 班博², 张梅^2*, 潘慧^1*

1.中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室,北京 100730;
2.济宁医学院附属医院内分泌科,山东济宁 272000

收稿日期:2024-08-20 修回日期:2024-11-19 出版日期:2025-04-05 发布日期:2025-03-24
通讯作者: ^*zhangmeijn@163.com; panhui20111111@163.com
作者简介:^#对本文有相同贡献
基金资助:
国家重点研发计划“主动健康和人口老龄化科技应对”重点专项(2022YFC3600203, 2022YFC3600202);中央高水平医院临床科研专项青年项目(2022-PUMCH-A-154)

Effect of exercise on the function and size of the liver in adolescents

ZHANG Liyuan^1#, GUO Xiaoyuan^1#, DU Hanze¹, CHEN Shi¹, BAN Bo², ZHANG Mei^2*, PAN Hui^1*

1. Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730;
2. Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining 272000, China

Received:2024-08-20 Revised:2024-11-19 Online:2025-04-05 Published:2025-03-24

摘要/Abstract

摘要： 目的　评价运动对青少年肝脏功能及大小的影响。方法　选取山东省济宁地区共计361名青少年受试者,按照运动频率不同分为低、中、高强度运动组,通过体检测试包括形态学指标、血液生化指标和肝脏大小以及是否患非酒精性脂肪肝。采用SPSS 26.0进行独立样本t检验和方差分析,相关因素分析采用斯皮尔曼相关性分析及多因素线性回归分析。结果　高强度运动组与中、低运动强度组相比:舒张压及胰岛素抵抗指数、三酰甘油(TG)均显著降低,身高、肝右叶最大斜径及直接胆红素(DBIL)显著升高。相关因素分析结果显示随着运动强度增加,天门冬氨酸氨基转移酶/丙氨酸氨基转移酶、DBIL及肝右叶最大斜径明显增加(P＜0.05)。运动类型与运动强度的叠加效应结果表明运动类型不影响运动强度对肝脏功能和大小的作用。结论　青少年定期运动不仅可以改善身体形态和糖脂代谢,随着运动强度增加,还可以使肝功能生理性升高。

关键词: 运动, 青少年, 肝脏功能, 肝右叶最大斜径

Abstract: Objective To evaluate the effects of physical exercise on liver function and size in adolescents. Methods A total of 361 adolescent subjects from Jining,Shandong Province were selected and divided into low, moderate, and high-intensity exercise groups according to the frequency of moderate intensity exercise. Physical examination tests were conducted including morphological indicators, blood biochemical indicator measurements, liver size and the presence of non-alcoholic fatty liver disease. Independent sample t-tests and variance analysis were performed using SPSS 26.0, and correlation analysis was conducted using Spearman correlation analysis and multivariate linear regression analysis. Results Compared with the moderate and low-intensity exercise groups, the high-intensity exercise group had significantly lower diastolic blood pressure, homeostatic model assessment of insulin resistance (HOMA-IR), and triglycerides (TG), as well as significantly higher height, maximum oblique diameter of the right liver lobe, and direct bilirubin (DBIL). Correlation analysis showed that as exercise intensity increased, aspartate aminotransferase/alanine aminotransferase, DBIL, and the maximum oblique diameter of the right liver lobe increased significantly (P＜0.05). The results of the cumulative effect of exercise type and intensity indicate that exercise type does not influence the effect of exercise intensity on liver function and size. Conclusions Regular exercise in adolescents can not only shape body, but also improve glucose and lipid metabolism and enhance liver function.

Key words: exercise, adolescents, liver function, the maximum oblique diameter of the right liver lobe

中图分类号:

R873

张沥元, 郭晓湲, 杜函泽, 陈适, 班博, 张梅, 潘慧. 运动对青少年肝脏功能及大小的影响[J]. 基础医学与临床, 2025, 45(4): 517-521.

ZHANG Liyuan, GUO Xiaoyuan, DU Hanze, CHEN Shi, BAN Bo, ZHANG Mei, PAN Hui. Effect of exercise on the function and size of the liver in adolescents[J]. Basic & Clinical Medicine, 2025, 45(4): 517-521.

参考文献

[1] Oliveira DT, Chaves-Filho AB, Yoshinaga MY, et al. Liver lipidome signature and metabolic pathways in nonalcoholic fatty liver disease induced by a high-sugar diet[J]. J Nutr Biochem, 2021, 87:108519. doi: 10.1016/j.jnutbio.2020.108519.
[2] Jafarikhah R, Damirchi A, Rahmani Nia F, et al. Effect of functional resistance training on the structure and function of the heart and liver in patients with non-alcoholic fatty liver[J]. Sci Rep, 2023, 13:15475. doi: 10.1038/s41598-023-42687-w.
[3] Romagnoli M, Alis R, Aloe R, et al. Influence of training and a maximal exercise test in analytical variability of muscular, hepatic, and cardiovascular biochemical variables[J]. Scand J Clin Lab Invest, 2014, 74:192-198.
[4] Pradas F, Falcón D, Pearrubia-Lozano C, et al. Effects of ultratrail running on neuromuscular function, muscle damage and hydration status. Differences according to training level[J]. Int J Environ Res Public Health, 2021, 18:5119. doi: 10.3390/ijerph18105119.
[5] Khatri P, Neupane A, Sapkota SR, et al. Strenuous exercise-induced tremendously elevated transaminases levels in a healthy adult: a diagnostic dilemma[J]. Case Reports Hepatol, 2021, 2021:6653266. doi: 10.1155/2021/6653266.
[6] 张菲菲,邵缨博,颉鸿笙,等. 抑郁-焦虑-压力在大学生锻炼成瘾风险中的作用[J]. 中华行为医学与脑科学杂志,2024,33:265-270.
[7] Haskell WL, Lee IM, Pate RR, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association[J]. Med Sci Sports Exerc,2007,39:1423-1434.
[8] 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病诊疗指南(2010年修订版)[J]. 中华肝脏病杂志,2010,18:163-166.
[9] Shephard RJ, Johnson N. Effects of physical activity upon the liver[J]. Eur J Appl Physiol, 2015, 115:1-46.
[10] 潘丽英,马春莲,谷涌泉. 6周有氧运动改善不同程度肥胖青少年体质健康的研究[J].武汉体育学院学报, 2022, 56:76-83.
[11] Amanat S, Ghahri S, Dianatinasab A, et al. Exerciseand type 2 diabetes[J]. Adv Exp Med Biol, 2020, 1228: 91-105.
[12] Ruiz JR, Labayen I, Ortega FB, et al. Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study[J]. Pediatr Res, 2014, 75:798-802.
[13] Hanley AJ, Williams K, Festa A, et al. Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study[J]. Diabetes, 2005, 54:3140-3147.
[14] Pettersson J, Hindorf U, Persson P, et al. Muscular exercise can cause highly pathological liver function tests in healthy men[J]. Br J Clin Pharmacol, 2008, 65:253-259.
[15] Patel DA, Srinivasan SR, Xu JH, et al. Persistent elevation of liver function enzymes within the reference range is associated with increased cardiovascular risk in young adults: the Bogalusa Heart Study[J]. Metabolism, 2007, 56:792-798.

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运动对青少年肝脏功能及大小的影响

Effect of exercise on the function and size of the liver in adolescents

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