Abstract:

Objective  To investigate the prevalence, diagnosis and treatment of depression, anxiety, psychiatric symptom, cognitive impairment and motor complications of Parkinson's disease (PD).  Methods  Face to face interview was carried out among patients with idiopathic PD from Outpatient Department of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine from March to May 2015. Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS), Mini-Mental State Examination (MMSE) were used for evaluation of depression, anxiety and cognitive impairment.  Results  A total of 55 patients with PD were enrolled in this study. Prevalences of depression, anxiety, psychiatric symptom and cognitive impairment of PD were 16.36% (9/55), 14.55% (8/55), 23.64% (13/55) and 9.09% (5/55), respectively. Ratio of previous diagnosis and treatment were 2/9, 2/8, 2/13 and 1/5, respectively. Prevalences of fluctuation and dyskinesia were 27.27% (15/55) and 9.09% (5/55), separately. There were no significant differences in prevalences of depression (P = 0.858), anxiety (P = 0.188), psychiatric symptom (P = 0.926), cognitive impairment (P = 0.286), fluctuation (P = 0.205) or dyskinesia (P = 0.417) between male and female PD patients.  Conclusions  Prevalences of depression, anxiety, psychiatric symptom, cognitive impairment and motor complications of PD were high, while ratios of diagnosis and treatment were relatively low.

Key words: Parkinson disease, Depression, Anxiety, Mental disorders, Cognition disorders, Cross-sectional studies

摘要：

目的 调查目前国内帕金森病患者抑郁、焦虑、精神症状、认知功能障碍和运动并发症患病率及既往诊断与治疗情况。方法 采用横断面研究，对2015 年3-5 月在上海交通大学医学院附属瑞金医院神经科帕金森病专病门诊就诊的原发性帕金森病患者进行面对面调查，采用抑郁自评量表、焦虑自评量表和简易智能状态检查量表评价患者抑郁、焦虑和认知功能障碍。结果 共纳入55 例帕金森病患者，抑郁、焦虑、精神症状和认知功能障碍患病率分别为16.36%（9/55）、14.55%（8/55）、23.64%（13/55） 和9.09%（5/55），既往诊断与治疗率分别为2/9、2/8、2/13 和1/5；运动并发症之症状波动和异动症患病率为27.27%（15/55）和9.09%（5/55）。男性与女性患者抑郁（P = 0.858）、焦虑（P = 0.188）、精神症状（P = 0.926）、认知功能障碍（P = 0.286），以及症状波动（P = 0.205）和异动症（P = 0.417）患病率差异均无统计学 意义。结论 帕金森病患者抑郁、焦虑、精神症状、认知功能障碍和运动并发症患病率较高，而诊断与治疗率较低。

关键词: 帕金森病, 抑郁, 焦虑, 精神障碍, 认知障碍, 横断面研究