Abstract: Interleukin-1beta (IL-1β), a pro-inflammatory cytokine, has been implicated in the development of peripheral and central sensitization that is charactistic of neuropathic pain. Recent studies demonstrated that IL-1β is an important messenger that is interacted with glia and neurons in the central neurous system in the neuropathic pain states. Some new studies showed that IL-1β activation was regulated by several other cytokines such as CCL2, MMP-2 and MMP-9 during the neuropathic pain conditions. This review will briefly describe the key role of IL-1 β and its signaling contributes to the peripheral and central nervous system in the neuropathic pain.

Key words: Interleukin-1beta, Neuralgia, Cytokines, Neuroglia

摘要： 炎性因子白细胞介素-1β（IL-1β）参与神经病理性疼痛的中枢和周围敏化过程，此为其特征性病理变化。IL-1β是介导中枢神经系统胶质细胞与神经元相互作用的重要炎性因子，其活化受到其他炎性因子的调控，如趋化细胞因子配体2（CCL2）和基质金属蛋白酶2、9（MMP-2、9）等。本文简要概述IL-1β在中枢性和周围性神经病理性疼痛中的主要作用机制。

关键词: 白细胞介素1β, 神经痛, 细胞因子类, 神经胶质