Abstract: Objective To explore the application value of low frequency repetitive transcranial magnetic stimulation (rTMS) in Parkinson's disease (PD) patients and electrophysiological research. Methods Fifty-six PD patients treated in the Department of Neurology of our hospital from September 2010 to September 2012 were randomly divided into 2 groups, group A (N = 28) and group B (N = 28). Patients in group A were given conventional drug treatment and rehabilitation training, while patients in group B were given low frequency rTMS on the basis of conventional drug treatment and rehabilitation training. After 3 weeks, the scores of Unified Parkinson's Disease Rating Scale (UPDRS), resting threshold (RT), cortical latent period, nerve root latent period, central motor conduction time (CMCT) and the incidence of adverse reactions were compared between 2 groups. Results After intervention, the emotion, ability of daily living and motor function of patients in group B was obviously improved, and the scores of UPDRS in group B were significantly lower than that in group A (P < 0.05, for all). The RT, cortical latent period and CMCT in group B were longer than that in group A (P < 0.05, for all). The incidence of adverse reactions of 2 groups was not obviously different (P > 0.05). Conclusion The effect of low frequency rTMS in the treatment for PD is evident, safe and reliable, and with less adverse reaction. It can be used as a noninvasive physical treatment measure for PD.

Key words: Parkinson disease, Transcranial magnetic stimulation, Rehabilitation, Electrophysiology

摘要： 目的 探讨低频重复经颅磁刺激在帕金森病康复治疗中的应用价值及电生理学研究方法。方法 选择56 例符合纳入条件的帕金森病患者，随机分为常规药物治疗和康复训练组（A 组）及常规治疗辅助低频重复经颅磁刺激治疗组（B 组），连续治疗3 周后评价两组患者统一帕金森病评价量表（UPDRS）评分、静息阈值、皮质潜伏期、神经根潜伏期、中枢运动传导时间和不良反应发生率。结果 与A 组相比，低频重复经颅磁刺激治疗后B 组患者UPDRS 评分降低，精神行为情绪、日常生活活动能力和运动功能改善，组间差异具有统计学意义（均P < 0.05），与此同时静息阈值升高、皮质潜伏期和中枢运动传导时间延长，差异亦有统计学意义（均P < 0.05）。两组患者不良反应发生率差异无统计学意义（P > 0.05）。结论 低频重复经颅磁刺激治疗帕金森病疗效确切、安全可靠、不良反应少，可作为一项无创性物理治疗帕金森病的措施。

关键词: 帕金森病, 经颅磁刺激, 康复, 电生理学