帕金森病睡眠障碍与认知功能障碍关系研究进展

doi:10.3969/j.issn.1672-6731.2022.03.004

摘要/Abstract

摘要： 睡眠障碍和认知功能障碍是帕金森病的常见非运动症状，不同类型睡眠障碍与认知功能障碍之间存在密切联系，但目前对其病理生理学机制尚不明确。本文拟对帕金森病睡眠障碍的病理生理学机制以及不同类型睡眠障碍与认知功能障碍之间的关系进行综述，以期实现对帕金森病睡眠障碍的早识别、早诊断、早干预，达到延缓认知功能减退、改善生活质量之目的。

关键词: 帕金森病, 睡眠觉醒障碍, 认知障碍, 综述

Abstract: Sleep disorders and cognitive dysfunction are common non-motor symptoms of Parkinson's disease (PD). There is a close relationship between different sleep disorders and cognitive dysfunction. However, the pathophysiological mechanism is still unclear. This article intends to review the pathophysiological mechanism of sleep disorders in PD and the relationship between different sleep disorders and cognitive dysfunction for early identification, early diagnosis, and early intervention of sleep disorders. Based on this, we can delay cognitive decline of patients with PD and improve quality of life.

Key words: Parkinson disease, Sleep wake disorders, Cognition disorders, Review

周传彬, 尹雷, 徐忠. 帕金森病睡眠障碍与认知功能障碍关系研究进展[J]. 中国现代神经疾病杂志, 2022, 22(3): 142-146.

ZHOU Chuan-bin, YIN Lei, XU Zhong. Advances in research on the association between sleep disorders and cognitive dysfunction in Parkinson's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2022, 22(3): 142-146.

http://journal11.magtechjournal.com/cjcnn/CN/Y2022/V22/I3/142

参考文献

[1] Hurt CS, Rixon L, Chaudhuri KR, Moss-Morris R, Samuel M, Brown RG. Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's[J]. Parkinsonism Relat Disord, 2019, 64:220-225.
[2] Yang Z, Zhang X, Li C, Chi S, Xie A. Molecular mechanisms underlying reciprocal interactions between sleep disorders and Parkinson's disease[J]. Front Neurosci, 2021, 14:592989.
[3] Chahine LM, Amara AW, Videnovic A. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015[J]. Sleep Med Rev, 2017, 35:33-50.
[4] Bugalho P, Magriço M, Alves L, Borbinha C. Objective sleep data as predictors of cognitive decline in dementia with Lewy bodies and Parkinson's disease[J]. Sleep Med, 2021, 80:273-278.
[5] Montanaro E, Romagnolo A, Fabbri M, Artusi CA, Imbalzano G, Rizzone MG, Lopiano L, Zibetti M. Association between sleep disorders and cognitive dysfunctions in non-demented patients with advanced Parkinson's disease[J]. J Neurol, 2021.[Epub ahead of print]
[6] Maggi G, Trojano L, Barone P, Santangelo G. Sleep disorders and cognitive dysfunctions in Parkinson's disease:a meta-analytic study[J]. Neuropsychol Rev, 2021.[Epub ahead of print]
[7] Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease[J]. Neurobiol Aging, 2003, 24:197-211.
[8] Dauvilliers Y, Schenck CH, Postuma RB, Iranzo A, Luppi PH, Plazzi G, Montplaisir J, Boeve B. REM sleep behaviour disorder[J]. Nat Rev Dis Primers, 2018, 4:19.
[9] Vegas-Suarez S, Paredes-Rodriguez E, Aristieta A, Lafuente JV, Miguelez C, Ugedo L. Dysfunction of serotonergic neurons in Parkinson's disease and dyskinesia[J]. Int Rev Neurobiol, 2019, 146:259-279.
[10] Wang L, Yan Y, Zhang L, Liu Y, Luo R, Chang Y. Substantia nigra neuromelanin magnetic resonance imaging in patients with different subtypes of Parkinson disease[J]. J Neural Transm (Vienna), 2021, 128:171-179.
[11] Baiano C, Barone P, Trojano L, Santangelo G. Prevalence and clinical aspects of mild cognitive impairment in Parkinson's disease:a meta-analysis[J]. Mov Disord, 2020, 35:45-54.
[12] Aarsland D, Batzu L, Halliday GM, Geurtsen GJ, Ballard C, Ray Chaudhuri K, Weintraub D. Parkinson disease-associated cognitive impairment[J]. Nat Rev Dis Primers, 2021, 7:47.
[13] Thompson K, Gibbings A, Shaw J, Ray L, Hébert G, De Koninck J, Fogel S. Sleep and second-language acquisition revisited:the role of sleep spindles and rapid eye movements[J]. Nat Sci Sleep, 2021, 13:1887-1902.
[14] Sánchez-Mora J, Tamayo RM. From incidental learning to explicit memory:the role of sleep after exposure to a serial reaction time task[J]. Acta Psychol (Amst), 2021, 217:103325.
[15] Cressman EK, Salomonczyk D, Constantin A, Miyasaki J, Moro E, Chen R, Strafella A, Fox S, Lang AE, Poizner H, Henriques DYP. Proprioceptive recalibration following implicit visuomotor adaptation is preserved in Parkinson's disease[J]. Exp Brain Res, 2021, 239:1551-1565.
[16] Qin S, Jiang J, Wu WZ, Wang XQ, Xi HQ, Fang QQ, Xu B, Liu CY. Effect of acupuncture on cognitive function of insomnia patients compared with drugs:a protocol for meta-analysis and systematic review[J]. Behav Neurol, 2021:ID6158275.
[17] Muslimovic D, Post B, Speelman JD, Schmand B. Cognitive profile of patients with newly diagnosed Parkinson disease[J]. Neurology, 2005, 65:1239-1245.
[18] Nofzinger EA, Buysse DJ, Germain A, Price JC, Miewald JM, Kupfer DJ. Functional neuroimaging evidence for hyperarousal in insomnia[J]. Am J Psychiatry, 2004, 161:2126-2128.
[19] Simuni T, Caspell-Garcia C, Coffey C, Chahine LM, Lasch S, Oertel WH, Mayer G, Högl B, Postuma R, Videnovic A, Amara AW, Marek K; PPMI Sleep Working group on behalf of the PPMI Investigators. Correlates of excessive daytime sleepiness in de novo Parkinson's disease:a case control study[J]. Mov Disord, 2015, 30:1371-1381.
[20] Amara AW, Chahine LM, Caspell-Garcia C, Long JD, Coffey C, Högl B, Videnovic A, Iranzo A, Mayer G, Foldvary-Schaefer N, Postuma R, Oertel W, Lasch S, Marek K, Simuni T; Parkinson's Progression Markers Initiative. Longitudinal assessment of excessive daytime sleepiness in early Parkinson's disease[J]. J Neurol Neurosurg Psychiatry, 2017, 88:653-662.
[21] Jester DJ, Lee S, Molinari V, Volicer L. Cognitive deficits in Parkinso's disease with excessive daytime sleepiness:a systematic review[J]. Aging Ment Health, 2020, 24:1769-1780.
[22] Hirano S. Clinical implications for dopaminergic and functional neuroimage research in cognitive symptoms of Parkinson's disease[J]. Mol Med, 2021, 27:40.
[23] Rist PM, Elbaz A, Dufouil C, Tzourio C, Kurth T. Restless legs syndrome and cognitive function:a population-based cross-sectional study[J]. Am J Med, 2015, 128:1023.e33-39.
[24] Li G, Tang H, Chen J, Qi X, Chen S, Ma J. Executive and visuospatial dysfunction in patients with primary restless legs syndrome/Willis-Ekbom disease:study of a Chinese population[J]. J Clin Sleep Med, 2018, 14:785-790.
[25] Cederberg KL, Brinkley EB, Belotserkovkaya N, Memon RA, Motl RW, Amara AW. Does restless legs syndrome impact cognitive function via sleep quality in adults with Parkinson's disease[J]? Int J Neurosci, 2020, 130:322-329.
[26] Chan L, Chung CC, Chen JH, Yu RC, Hong CT. Cytokine profile in plasma extracellular vesicles of Parkinson's disease and the association with cognitive function[J]. Cells, 2021, 10:604.
[27] Dodson C, Bagai K, Weinstock LB, Thompson E, Okamoto LE, Peltier A, Raj SR, Walters AS. Restless legs syndrome is increased in postural orthostatic tachycardia syndrome[J]. J Clin Sleep Med, 2021, 17:791-795.
[28] Verbaan D, van Rooden SM, van Hilten JJ, Rijsman RM. Prevalence and clinical profile of restless legs syndrome in Parkinson's disease[J]. Mov Disord, 2010, 25:2142-2147.
[29] Bekdash RA. The cholinergic system, the adrenergic system and the neuropathology of Alzheimer's disease[J]. Int J Mol Sci, 2021, 22:1273.
[30] Zou HL, Zhao XC, Jiang YC, Lei GS, Yang WY, Su CJ. Study on rapid eye movement sleep behavior disorder in patients with Parkinson's disease at early stage[J]. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi, 2017, 17:736-740.[邹慧莉, 赵显超, 江应聪, 雷革胜, 杨伟毅, 宿长军. 早期帕金森病患者快速眼动睡眠期行为障碍研究[J]. 中国现代神经疾病杂志, 2017, 17:736-740.]
[31] Zhang H, Chan P. Meta-analysis of clinical differences between Parkinson's disease patients with and without REM sleep behavior disorder[J]. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi, 2013, 13:574-581.[张慧, 陈彪. 伴与不伴快速眼动睡眠期行为障碍的帕金森病临床特征差异的Meta分析[J]. 中国现代神经疾病杂志, 2013, 13:574-581.]
[32] Ma LJ, Fu YT, Shen Y, Wang Y, Li J, Mao CJ, Han F, Liu CF. Study on the correlation between two common sleep disorders in Parkinson's disease[J]. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi, 2017, 17:31-38.[马丽婧, 傅蕴婷, 沈赟, 王益, 李洁, 毛成洁, 韩菲, 刘春风. 帕金森病两种常见睡眠障碍关联性研究[J]. 中国现代神经疾病杂志, 2017, 17:31-38.]
[33] Trošt M, Perovnik M, Pirtošek Z. Correlations of neuropsychological and metabolic brain changes in Parkinson's disease and other alpha-synucleinopathies[J]. Front Neurol, 2019, 10:1204.
[34] Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Neurochemical features of rem sleep behaviour disorder[J]. J Pers Med, 2021, 11:880.
[35] Pagano G, De Micco R, Yousaf T, Wilson H, Chandra A, Politis M. REM behavior disorder predicts motor progression and cognitive decline in Parkinson disease[J]. Neurology, 2018, 91:e894-905.
[36] Pasquini J, Brooks DJ, Pavese N. The cholinergic brain in Parkinson's disease[J]. Mov Disord Clin Pract, 2021, 8:1012-1026.
[37] Sommerauer M, Fedorova TD, Hansen AK, Knudsen K, Otto M, Jeppesen J, Frederiksen Y, Blicher JU, Geday J, Nahimi A, Damholdt MF, Brooks DJ, Borghammer P. Evaluation of the noradrenergic system in Parkinson's disease:an 11C-MeNER PET and neuromelanin MRI study[J]. Brain, 2018, 141:496-504.
[38] Gosselin N, Baril AA, Osorio RS, Kaminska M, Carrier J. Obstructive sleep apnea and the risk of cognitive decline in older adults[J]. Am J Respir Crit Care Med, 2019, 199:142-148.
[39] Zuzuárregui JRP, During EH. Sleep issues in Parkinson's disease and their management[J]. Neurotherapeutics, 2020, 17:1480-1494.
[40] Elfil M, Bahbah EI, Attia MM, Eldokmak M, Koo BB. Impact of obstructive sleep apnea on cognitive and motor functions in Parkinson's disease[J]. Mov Disord, 2021, 36:570-580.
[41] Harmell AL, Neikrug AB, Palmer BW, Avanzino JA, Liu L, Maglione JE, Natarajan L, Corey-Bloom J, Loredo JS, Ancoli-Israel S. Obstructive sleep apnea and cognition in Parkinson's disease[J]. Sleep Med, 2016, 21:28-34.
[42] Shi Y, Chen L, Chen T, Li L, Dai J, Lui S, Huang X, Sweeney JA, Gong Q. A meta-analysis of voxel-based brain morphometry studies in obstructive sleep apnea[J]. Sci Rep, 2017, 7:10095.
[43] Docu Axelerad A, Stroe AZ, Arghir OC, Docu Axelerad D, Gogu AE. Respiratory dysfunctions in Parkinson's disease patients[J]. Brain Sci, 2021, 11:595.

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Advances in research on the association between sleep disorders and cognitive dysfunction in Parkinson's disease

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