发作性睡病与焦虑研究进展

doi:10.3969/j.issn.1672-6731.2023.08.005

摘要/Abstract

摘要：

发作性睡病是以日间过度思睡、猝倒发作、入睡前幻觉、睡眠瘫痪为主要临床表现的罕见睡眠障碍，绝大多数患者伴焦虑。发作性睡病与焦虑的神经回路之间存在神经元的相互连接与投射，二者可能存在共同的病理生理学机制，且部分用于治疗发作性睡病猝倒发作的药物可改善焦虑。本研究对发作性睡病伴焦虑的流行病学、发病机制和治疗进行综述，以提高临床对发作性睡病伴焦虑的诊断与治疗水平，改善患者预后。

关键词: 发作性睡病, 焦虑, 综述

Abstract:

Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness (EDS), cataplexy, sleep hallucination and sleep paralysis, and the vast majority of patients are accompanied by anxiety. There are neuronal interconnections and projections between the neural circuits of narcolepsy and anxiety, which may share common pathophysiology mechanisms, and some medications used clinically to treat cataplexy in narcolepsy may also improve anxiety. In this study, we propose to review the epidemiologic research, pathogenesis and therapeutic advances in narcolepsy with anxiety, with the aim of increasing the diagnosis and treatment of narcolepsy with anxiety and improving the prognosis of narcolepsy with anxiety patients.

Key words: Narcolepsy, Anxiety, Review

于洁洋, 张亚男, 李惠敏, 黄真灿, 李宛儒, 王赞. 发作性睡病与焦虑研究进展[J]. 中国现代神经疾病杂志, 2023, 23(8): 678-682.

Jie-yang YU, Ya-nan ZHANG, Hui-min LI, Zhen-can HUANG, Wan-ru LI, Zan WANG. Progress on narcolepsy and anxiety[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2023, 23(8): 678-682.

http://journal11.magtechjournal.com/cjcnn/CN/Y2023/V23/I8/678

参考文献 62

1	Dodet P , Noiray C , Leu-Semenescu S , Lefevre E , Nigam M , Faucher P , Maranci JB , Jublanc C , Poitou C , Arnulf I . Hypersomnia and narcolepsy in 42 adult patients with craniopharyngioma. Sleep, 2023, 46: zsad032. doi: 10.1093/sleep/zsad032
2	Melzi S , Prevot V , Peyron C . Precocious puberty in narcolepsy type 1:orexin loss and/or neuroinflammation, which is to blame?. Sleep Med Rev, 2022, 65: 101683. doi: 10.1016/j.smrv.2022.101683
3	Wang Y , Sun Q , Tang Q , Zhang Y , Tang M , Wang D , Wang Z . Progress of autonomic disturbances in narcolepsy type 1. Front Neurol, 2023, 14: 1107632. doi: 10.3389/fneur.2023.1107632
4	Tiseo C , Vacca A , Felbush A , Filimonova T , Gai A , Glazyrina T , Hubalek IA , Marchenko Y , Overeem LH , Piroso S , Tkachev A , Martelletti P , Sacco S , European Headache Federation School of Advanced Studies (EHF-SAS) . Migraine and sleep disorders: a systematic review. J Headache Pain, 2020, 21: 126. doi: 10.1186/s10194-020-01192-5
5	Mahoney CE , Cogswell A , Koralnik IJ , Scammell TE . The neurobiological basis of narcolepsy. Nat Rev Neurosci, 2019, 20: 83- 93. doi: 10.1038/s41583-018-0097-x
6	Yu JY. The study on brain function state of narcolepsy patients[D]. Changchun: Jilin University, 2021.
	于洁洋. 发作性睡病患者的脑功能状态研究[D]. 长春: 吉林大学, 2021.
7	Quaedackers L , Van Gilst MM , Van Den Brandt I , Vilanova A , Lammers GJ , Markopoulos P , Overeem S . The burden of narcolepsy in adults: a population sampling study using personal media. Behav Sleep Med, 2023, 29: 1- 11.
8	Fortuyn HA , Lappenschaar MA , Furer JW , Hodiamont PP , Rijnders CA , Renier WO , Buitelaar JK , Overeem S . Anxiety and mood disorders in narcolepsy: a case-control study. Gen Hosp Psychiatry, 2010, 32: 49- 56. doi: 10.1016/j.genhosppsych.2009.08.007
9	Park SC , Kim YK . Anxiety disorders in the DSM-5:changes, controversies, and future directions. Adv Exp Med Biol, 2020, 1191: 187- 196.
10	Showraki M , Showraki T , Brown K . Generalized anxiety disorder: revisited. Psychiatr Q, 2020, 91: 905- 914. doi: 10.1007/s11126-020-09747-0
11	Beesdo K , Knappe S , Pine DS . Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-Ⅴ. Psychiatr Clin North Am, 2009, 32: 483- 524. doi: 10.1016/j.psc.2009.06.002
12	Ruoff CM , Reaven NL , Funk SE , McGaughey KJ , Ohayon MM , Guilleminault C , Black J . High rates of psychiatric comorbidity in narcolepsy: findings from the burden of narcolepsy disease(BOND) study of 9, 312 patients in the United States. J Clin Psychiatry, 2017, 78: 171- 176. doi: 10.4088/JCP.15m10262
13	Alasim H , AlQazlan S , Albanyan S , Alsalhi A , Buraik A , Olaish AH , Almeneessier AS , Alosaimi FD , AlHadi A , BaHammam AS . Comorbid psychiatric disorders among patients with narcolepsy. Sleep Breath, 2020, 24: 629- 636. doi: 10.1007/s11325-019-01890-8
14	Abenza-Abildua MJ , Suárez-Gisbert E , Lores-Gutiérrez V , Algarra-Lucas C , Gómez-Aceña Á , Navacerrada-Barrero FJ , González-Martín L , Pérez-Villena A , Pérez-López C . Anxiety and depression in patients with narcolepsy. J Sleep Res, 2023, 32: e13812. doi: 10.1111/jsr.13812
15	Chen TY , Huang CH , Chung CH , Mao WC , Yeh CB , Yang CCH , Kuo TBJ , Yang SS , Chien WC , Tzeng NS . Sex and age differences in the association between anxiety disorders and narcolepsy: a nationwide population-based case control study. J Affect Disord, 2020, 264: 130- 137. doi: 10.1016/j.jad.2019.12.010
16	Szakács A , Hallböök T , Tideman P , Darin N , Wentz E . Psychiatric comorbidity and cognitive profile in children with narcolepsy with or without association to the H1N1 influenza vaccination. Sleep, 2015, 38: 615- 621. doi: 10.5665/sleep.4582
17	Ohayon MM . Narcolepsy is complicated by high medical and psychiatric comorbidities: a comparison with the general population. Sleep Med, 2013, 14: 488- 492. doi: 10.1016/j.sleep.2013.03.002
18	Cohen A , Mandrekar J , St Louis EK , Silber MH , Kotagal S . Comorbidities in a community sample of narcolepsy. Sleep Med, 2018, 43: 14- 18. doi: 10.1016/j.sleep.2017.11.1125
19	Gudka S , Haynes E , Scotney J , Mukherjee S , Frenkel S , Sivam S , Swieca J , Chamula K , Cunnington D , Saini B . Narcolepsy: comorbidities, complexities and future directions. Sleep Med Rev, 2022, 65: 101669. doi: 10.1016/j.smrv.2022.101669
20	Flosnik DL , Cortese BM , Uhde TW . Cataplexy in anxious patients: is subclinical narcolepsy underrecognized in anxiety disorders?. J Clin Psychiatry, 2009, 70: 810- 816. doi: 10.4088/JCP.08m04272
21	Farooq M , Anjum F . Sleep Paralysis. Treasure Island (FL): StatPearls Publishing, 2023.
22	Denis D , French CC , Gregory AM . A systematic review of variables associated with sleep paralysis. Sleep Med Rev, 2018, 38: 141- 157. doi: 10.1016/j.smrv.2017.05.005
23	Wróbel-Knybel P , Flis M , Rog J , Jalal B , Wołkowski L , Karakuła-Juchnowicz H . Characteristics of sleep paralysis and its association with anxiety symptoms, perceived stress, PTSD, and other variables related to lifestyle in selected high stress exposed professions. Int J Environ Res Public Health, 2022, 19: 7821. doi: 10.3390/ijerph19137821
24	Otto MW , Simon NM , Powers M , Hinton D , Zalta AK , Pollack MH . Rates of isolated sleep paralysis in outpatients with anxiety disorders. J Anxiety Disord, 2006, 20: 687- 693. doi: 10.1016/j.janxdis.2005.07.002
25	Alasim H , AlQazlan S , Albanyan S , Alsalhi A , Buraik A , Olaish AH , Almeneessier AS , Alosaimi FD , AlHadi A , BaHammam AS . Comorbid psychiatric disorders among patients with narcolepsy. Sleep Breath, 2020, 24: 629- 636. doi: 10.1007/s11325-019-01890-8
26	Sakurai T , Amemiya A , Ishii M , Matsuzaki I , Chemelli RM , Tanaka H , Williams SC , Richarson JA , Kozlowski GP , Wilson S , Arch JR , Buckingham RE , Haynes AC , Carr SA , Annan RS , McNulty DE , Liu WS , Terrett JA , Elshourbagy NA , Bergsma DJ , Yanagisawa M . Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell, 1998, 92: 573- 585. doi: 10.1016/S0092-8674(00)80949-6
27	Marcus JN , Aschkenasi CJ , Lee CE , Chemelli RM , Saper CB , Yanagisawa M , Elmquist JK . Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol, 2001, 435: 6- 25. doi: 10.1002/cne.1190
28	Yaeger JDW , Krupp KT , Jacobs BM , Onserio BO , Meyerink BL , Cain JT , Ronan PJ , Renner KJ , DiLeone RJ , Summers CH . Orexin 1 receptor antagonism in the basolateral amygdala shifts the balance from pro-to antistress signaling and behavior. Biol Psychiatry, 2022, 91: 841- 852. doi: 10.1016/j.biopsych.2021.12.019
29	Staton CD , Yaeger JDW , Khalid D , Haroun F , Fernandez BS , Fernandez JS , Summers BK , Summers TR , Sathyanesan M , Newton SS , Summers CH . Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression. Neuropharmacology, 2018, 143: 79- 94. doi: 10.1016/j.neuropharm.2018.09.016
30	Summers CH , Yaeger JDW , Staton CD , Arendt DH , Summers TR . Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: potential for therapy. Brain Res, 2020, 1731: 146085. doi: 10.1016/j.brainres.2018.12.036
31	Arendt DH , Hassell J , Li H , Achua JK , Guarnieri DJ , Dileone RJ , Ronan PJ , Summers CH . Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala. Psychoneuroendocrinology, 2014, 40: 17- 26. doi: 10.1016/j.psyneuen.2013.10.010
32	Khalil R , Fendt M . Increased anxiety but normal fear and safety learning in orexin-deficient mice. Behav Brain Res, 2017, 320: 210- 218. doi: 10.1016/j.bbr.2016.12.007
33	Johnson PL , Molosh A , Fitz SD , Truitt WA , Shekhar A . Orexin, stress, and anxiety/panic states. Prog Brain Res, 2012, 198: 133- 161.
34	Jacobson LH , Hoyer D , de Lecea L . Hypocretins (orexins): the ultimate translational neuropeptides. J Intern Med, 2022, 291: 533- 556. doi: 10.1111/joim.13406
35	Del Sette P , Veneruso M , Cordani R , Lecce S , Varallo G , Franceschini C , Venturino C , Pizza F , Plazzi G , Nobili L . Narcolepsy and emotions: is there a place for a theory of mind approach?. Sleep Med, 2023, 102: 84- 89. doi: 10.1016/j.sleep.2022.12.013
36	Chellappa SL , Aeschbach D . Sleep and anxiety: from mechanisms to interventions. Sleep Med Rev, 2022, 61: 101583. doi: 10.1016/j.smrv.2021.101583
37	Winsky-Sommerer R , Yamanaka A , Diano S , Borok E , Roberts AJ , Sakurai T , Kilduff TS , Horvath TL , de Lecea L . Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci, 2004, 24: 11439- 11448. doi: 10.1523/JNEUROSCI.3459-04.2004
38	Flores-Ramirez FJ , Matzeu A , Sánchez-Marín L , Martin-Fardon R . Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: evidence of interaction between CRF1 and orexin receptor signaling. Neuropharmacology, 2022, 210: 109046. doi: 10.1016/j.neuropharm.2022.109046
39	James MH , Campbell EJ , Dayas CV . Role of the orexin/hypocretin system in stress-related psychiatric disorders. Curr Top Behav Neurosci, 2017, 33: 197- 219.
40	Prajapati SK , Krishnamurthy S . Non-selective orexin-receptor antagonist attenuates stress-restress-induced core PTSD-like symptoms in rats: behavioural and neurochemical analyses. Behav Brain Res, 2021, 399: 113015. doi: 10.1016/j.bbr.2020.113015
41	Strawn JR , Pyne-Geithman GJ , Ekhator NN , Horn PS , Uhde TW , Shutter LA , Baker DG , Geracioti TD Jr . Low cerebrospinal fluid and plasma orexin-A (hypocretin-1) concentrations in combat-related posttraumatic stress disorder. Psychoneuroendocrinology, 2010, 35: 1001- 1007. doi: 10.1016/j.psyneuen.2010.01.001
42	Wang YQ , Liu WY , Li L , Qu WM , Huang ZL . Neural circuitry underlying REM sleep: a review of the literature and current concepts. Prog Neurobiol, 2021, 204: 102106. doi: 10.1016/j.pneurobio.2021.102106
43	Garcia-Rill E . Disorders of the reticular activating system. Med Hypotheses, 1997, 49: 379- 387. doi: 10.1016/S0306-9877(97)90083-9
44	Breslau N , Roth T , Burduvali E , Kapke A , Schultz L , Roehrs T . Sleep in lifetime posttraumatic stress disorder: a community-based polysomnographic study. Arch Gen Psychiatry, 2004, 61: 508- 516. doi: 10.1001/archpsyc.61.5.508
45	Geracioti TD Jr , Baker DG , Ekhator NN , West SA , Hill KK , Bruce AB , Schmidt D , Rounds-Kugler B , Yehuda R , Keck PE Jr , Kasckow JW . CSF norepinephrine concentrations in posttraumatic stress disorder. Am J Psychiatry, 2001, 158: 1227- 1230. doi: 10.1176/appi.ajp.158.8.1227
46	Spoormaker VI , Montgomery P . Disturbed sleep in post-traumatic stress disorder: secondary symptom or core feature?. Sleep Med Rev, 2008, 12: 169- 184. doi: 10.1016/j.smrv.2007.08.008
47	Horváth A , Montana X , Lanquart JP , Hubain P , Szűcs A , Linkowski P , Loas G . Effects of state and trait anxiety on sleep structure: a polysomnographic study in 1083 subjects. Psychiatry Res, 2016, 244: 279- 283. doi: 10.1016/j.psychres.2016.03.001
48	Gann H , Riemann D , Hohagen F , Dressing H , Müller WE , Berger M . The sleep structure of patients with anxiety disorders in comparison to that of healthy controls and depressive patients under baseline conditions and after cholinergic stimulation. J Affect Disord, 1992, 26: 179- 189. doi: 10.1016/0165-0327(92)90014-W
49	Liang Y , Zhao X , Zhang C , Liu G , Lu B , Han L , Tong F , Luo X , Hu C , Liu H . Sleep misperception and associated factors in patients with anxiety-related disorders and complaint of insomnia: a retrospective study. Front Neurol, 2022, 13: 836949. doi: 10.3389/fneur.2022.836949
50	Alfano CA , Reynolds K , Scott N , Dahl RE , Mellman TA . Polysomnographic sleep patterns of non-depressed, non-medicated children with generalized anxiety disorder. J Affect Disord, 2013, 147: 379- 384. doi: 10.1016/j.jad.2012.08.015
51	Cox RC , Olatunji BO . Sleep in the anxiety-related disorders: a meta-analysis of subjective and objective research. Sleep Med Rev, 2020, 51: 101282. doi: 10.1016/j.smrv.2020.101282
52	Gottesmann C . GABA mechanisms and sleep. Neuroscience, 2002, 111: 231- 239. doi: 10.1016/S0306-4522(02)00034-9
53	Sleep Disorders Group, Neurology Branch, Chinese Medical Association . Chinese guidelines for diagnosis and treatment of narcolepsy (2022. Zhonghua Shen Jing Ke Za Zhi, 2022, 55: 406- 420. URL
	中华医学会神经病学分会睡眠障碍学组. 中国发作性睡病诊断与治疗指南(2022版). 中华神经科杂志, 2022, 55: 406- 420. URL
54	Dolder PC , Müller F , Schmid Y , Borgwardt SJ , Liechti ME . Direct comparison of the acute subjective, emotional, autonomic, and endocrine effects of MDMA, methylphenidate, and modafinil in healthy subjects. Psychopharmacology(Berl), 2018, 235: 467- 479. doi: 10.1007/s00213-017-4650-5
55	Sakai N , Nishino S . Comparison of solriamfetol and modafinil on arousal and anxiety-related behaviors in narcoleptic mice. Neurotherapeutics, 2023, 20: 546- 563. doi: 10.1007/s13311-022-01328-2
56	Sousa A , Dinis-Oliveira RJ . Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: relevant clinical and forensic aspects. Subst Abus, 2020, 41: 155- 173. doi: 10.1080/08897077.2019.1700584
57	Randall DC , Shneerson JM , Plaha KK , File SE . Modafinil affects mood, but not cognitive function, in healthy young volunteers. Hum Psychopharmacol, 2003, 18: 163- 173. doi: 10.1002/hup.456
58	Johnson A , Hamilton TJ . Modafinil decreases anxiety-like behaviour in zebrafish. PeerJ, 2017, 5: e2994. doi: 10.7717/peerj.2994
59	Malhotra A , Shapiro C , Pepin JL , Hedner J , Ahmed M , Foldvary-Schaefer N , Strollo PJ , Mayer G , Sarmiento K , Baladi M , Chandler P , Lee L , Schwab R . Long-term study of the safety and maintenance of efficacy of solriamfetol (JZP-110) in the treatment of excessive sleepiness in participants with narcolepsy or obstructive sleep apnea. Sleep, 2020, 43: zsz220. doi: 10.1093/sleep/zsz220
60	Lamb YN . Pitolisant: a review in narcolepsy with or without cataplexy. CNS Drugs, 2020, 34: 207- 218. doi: 10.1007/s40263-020-00703-x
61	Li S , Yang J . Pitolisant for treating patients with narcolepsy. Expert Rev Clin Pharmacol, 2020, 13: 79- 84. doi: 10.1080/17512433.2020.1714435
62	Krystal AD , Benca RM , Rosenberg R , Schweitzer PK , Malhotra A , Babson K , Lee L , Bujanover S , Strohl KP . Solriamfetol treatment of excessive daytime sleepiness in participants with narcolepsy or obstructive sleep apnea with a history of depression. J Psychiatr Res, 2022, 155: 202- 210. doi: 10.1016/j.jpsychires.2022.08.018

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