斑马鱼模型与脑出血遗传分子机制研究进展

doi:10.3969/j.issn.1672-6731.2021.02.005

中国现代神经疾病杂志 ›› 2021, Vol. 21 ›› Issue (2): 88-93. doi: 10.3969/j.issn.1672-6731.2021.02.005

2 斑马鱼模型与脑出血遗传分子机制研究进展

王雪琪¹, 郭睿³, 陈雨麒³, 刘翼³, 游潮³, 王业启², 田蕊³

1. 400030 重庆大学生物工程学院2018级;
2. 400030 重庆大学生物工程学院;
3. 610041 成都, 四川大学华西医院神经外科

收稿日期:2021-02-23 出版日期:2021-02-25 发布日期:2021-03-05
通讯作者: 田蕊,Email:tianrui17419@wchscu.cn;王业启,Email:yeqi.wang@cqu.edu.cn
基金资助:
国家重点研发计划“干细胞及转化研究”项目（项目编号：2018YFA0108603）；国家自然科学基金资助项目（项目编号：31771599）；四川大学华西医院学科卓越发展1·3·5工程临床研究孵化项目（项目编号：2021HXFH014）；华西医院院-企合作临床研究创新项目（项目编号：2019HXCX07）

Zebrafish model and intracranial hemorrhage: a review from genetic to molecular mechanism perspectives

WANG Xue-qi¹, GUO Rui³, CHEN Yu-qi³, LIU Yi³, YOU Chao³, WANG Ye-qi², TIAN Rui³

1 Grade 2018 of Bioengineering College, Chongqing University, Chongqing 400030, China;
2 Bioengineering College, Chongqing University, Chongqing 400030, China;
3 Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

Received:2021-02-23 Online:2021-02-25 Published:2021-03-05
Supported by:
This study was supported by National Key Research and Development "Stem Cells and Translational Research" Program of China (No. 2018YFA0108603), the National Natural Science Foundation of China (No. 31771599), 1·3·5 Project for Disciplines of Excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University (No. 2021HXFH014), and Clinical Research Innovation Project, West China Hospital, Sichuan University (No. 2019HXCX07).

摘要/Abstract

摘要：

脑出血是老年人常见的急性进行性脑血管病，大量基础研究提示，脑出血的病理学机制可能与不同遗传因子对血-脑屏障的调控与干预有关。斑马鱼脑出血模型作为出血性脑血管病研究的经典模型，在相关遗传分子机制研究中起重要作用，本文系统介绍斑马鱼脑出血模型的特点及优势，并基于常用转基因斑马鱼脑出血模型阐述斑马鱼血-脑屏障结构与功能完整性的遗传分子学研究现状、相关基因表达与脑出血致病机制研究进展，以加深对脑出血发病机制的理解，并协助制定相应防治策略。

关键词: 脑出血, 血脑屏障, 斑马鱼, 遗传学, 基因, 综述

Abstract:

Intracranial hemorrhage (ICH) is the most common acute progressive cerebrovascular disease in aging population. Although the pathogenesis of ICH remains unclear, a great many mechanism researches have shown that the blood-brain barrier (BBB) regulated by different genetic factors may play an important role. As classic animal model for hemorrhagic cerebrovascular disease, the ICH zebrafish model plays a key role in the studies for mechanisms of genetic factors. In this article, we comprehensively reviews the characteristics and advantages of ICH zebrafish model, and also makes an updated introductions on genetic and molecular aspects of BBB structures and functions based on common transgenic ICH zebrafish model. Therefore, we explain the relationship between ICH and related gene expression, in order to deepen current understanding on ICH pathogenesis and help to make relevant strategy for prevention and treatment.

Key words: Cerebral hemorrhage, Blood-brain barrier, Zebrafish, Genetics, Genes, Review

王雪琪, 郭睿, 陈雨麒, 刘翼, 游潮, 王业启, 田蕊. 斑马鱼模型与脑出血遗传分子机制研究进展[J]. 中国现代神经疾病杂志, 2021, 21(2): 88-93.

WANG Xue-qi, GUO Rui, CHEN Yu-qi, LIU Yi, YOU Chao, WANG Ye-qi, TIAN Rui. Zebrafish model and intracranial hemorrhage: a review from genetic to molecular mechanism perspectives[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2021, 21(2): 88-93.

http://journal11.magtechjournal.com/cjcnn/CN/Y2021/V21/I2/88

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