自身免疫性脑炎相关癫癎功能影像学研究进展

doi:10.3969/j.issn.1672-6731.2020.01.003

中国现代神经疾病杂志 ›› 2020, Vol. 20 ›› Issue (1): 9-14. doi: 10.3969/j.issn.1672-6731.2020.01.003

• 神经系统疾病免疫研究进展 • 上一篇下一篇

2 自身免疫性脑炎相关癫癎功能影像学研究进展

刘霄¹, 单伟^1,2, 张玉笛¹, 吕瑞娟¹, 王群^1,2

1. 100070 首都医科大学附属北京天坛医院神经病学中心癫痫科国家神经系统疾病临床医学研究中心;
2. 100069 北京脑重大疾病研究院

收稿日期:2020-01-10 出版日期:2020-01-25 发布日期:2020-01-21
通讯作者: 王群,Email:wangq@ccmu.edu.cn
基金资助:
国家重点研发计划项目（项目编号：2017YFC1307501）；京津冀基础研究合作专项项目（项目编号：H2018206435）；首都卫生发展科研专项项目（项目编号：首发2016-1-2011）

Progress in functional imaging of autoimmune encephalitis associated with epilepsy

LIU Xiao¹, SHAN Wei^1,2, ZHANG Yu-di¹, Lü Rui-juan¹, WANG Qun^1,2

1 Department of Epilepsy, Neurology Center, Beijing Tiantan Hospital, Capital Medical University;China National Clinical Research Center for Neurological Diseases, Beijing 100070, China;
2 Beijing Institute for Brain Disorders, Beijing 100069, China

Received:2020-01-10 Online:2020-01-25 Published:2020-01-21
Supported by:
This study was supported by National Key Research and Development Program of China (No. 2017YFC1307501), Beijing-Tianjin-Hebei Cooperative Basic Research Special Program (No. H2018206435), and Capital Health Development and Research Project (No. 2016-1-2011).

摘要/Abstract

摘要：

自身免疫性脑炎相关癫癎是一组重要的临床综合征，主要表现为难治性癫癎发作、认知功能障碍和精神症状，经早期诊断和免疫治疗后可获得良好预后，因此尽早诊断、及时治疗至关重要。随着神经影像学技术特别是功能影像学的发展，逐渐显现出显著的临床应用价值，在疾病诊断和预后评估中具有重要作用。通过综述国内外自身免疫性脑炎相关癫癎功能影像学研究进展，为早期识别、鉴别诊断和预后评估提供影像学依据。

关键词: 自身免疫疾病, 脑炎, 癫癎, 正电子发射断层显像术, 综述

Abstract:

Autoimmune encephalitis (AE) associated with epilepsy is a significant clinical syndrome, which is characterized by refractory seizures, cognitive deficits, neuropsychiatric disturbances. Many studies have been clearly notified that early diagnosis combined with immunotherapy can apparently improve prognosis, thus early diagnosis and treatment are highly essential. In recent years, the neuroimaging, especially functional imaging, plays a critical role in the early diagnosis and prognostic assessment of AE associated with epilepsy. This review summarized the methods and results of functional imaging in the diagnosis of epilepsy associated with AE, to provide an imaging basis for clinical and differential diagnosis and prognostic assessment.

Key words: Autoimmune diseases, Encephalitis, Epilepsy, Positron-emission tomography, Review

刘霄, 单伟, 张玉笛, 吕瑞娟, 王群. 自身免疫性脑炎相关癫癎功能影像学研究进展[J]. 中国现代神经疾病杂志, 2020, 20(1): 9-14.

LIU Xiao, SHAN Wei, ZHANG Yu-di, Lü Rui-juan, WANG Qun. Progress in functional imaging of autoimmune encephalitis associated with epilepsy[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(1): 9-14.

http://journal11.magtechjournal.com/cjcnn/CN/Y2020/V20/I1/9

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