摘要：

脑出血作为最重要的急性脑血管病之一，迄今尚缺乏有效治疗方法，因此迫切需要从脑出血发生与发展关键机制出发，凝练关键科学问题，开展基础与临床转化研究，为脑出血临床预防与治疗提供新策略。既往观点不能完全阐释脑出血的发生，借助现代基因测序技术有望丰富脑出血全新的发病机制。血肿和继发性脑组织损害是脑出血发展的关键环节，颅内血肿清除术理应是首选治疗方法，但还需要结合影像学等多学科手段，重视提高内源性神经保护作用等。

关键词: 脑出血, 转化, 遗传, 综述

Abstract:

Untill now, there is still no effective treatment for intracerebral hemorrhage (ICH), one of the most important acute cerebrovascular diseases. Therefore, it is urgent to carry out basic and clinical transformational research through the key mechanisms of ICH occurrence and development, and provide new strategies for clinical prevention and treatment of ICH. The previous views cannot fully explain the occurrence of ICH, but modern sequencing technology is expected to enrich new knowledge of the mechanisms of ICH. Hematoma formation and its secondary brain damage are the key links in the development of ICH. Hematoma clearance should be the first choice for the treatment of ICH, but it is also necessary to combine with multidisciplinary means such as imaging, and focus on enhancing the endogenous neuroprotection.

Key words: Cerebral hemorrhage, Transformation, genetic, Review