摘要：
目的 研究复发性视神经炎患者异常神经功能活动脑区的分布差异，探讨基线神经功能及其与临床的关系。方法 采用基于低频振幅（ALFF）的静息态fMRI技术对35 例复发性视神经炎患者进行研究，并与50例性别、年龄和受教育程度相匹配的正常对照者进行比较，并分析mALFF 值改变脑区与病程、同步听觉系列加法测验（PASAT）评分和视力之间的相关性。结果 与正常对照组相比，复发性视神经炎组患者左侧楔叶/楔前叶、左侧颞上回、双侧颞下回、双侧舌回和右侧枕中回mALFF 值降低（P < 0.01），而双侧额下回和左侧额叶内侧回mALFF 值增加（P < 0.01）。复发性视神经炎患者仅左侧颞上回（r = 0.403，P < 0.05）和右侧舌回（r = 0.472，P < 0.05）mALFF 值与病程呈正相关。结论 静息态fMRI可以检出复发性视神经炎患者参与视觉信息处理的颞枕叶神经功能降低，以及与脑默认网络相关的额叶神经功能增强，为早期评价视神经炎患者神经功能和预测预后提供客观依据。
关键词:
视神经炎,
复发,
磁共振成像
Abstract:
Objective To investigate the distribution of abnormal neurological activity of patients with recurrent optic neuritis (ON) by resting-state functional magnetic resonance imaging (fMRI), and to explore the relationship between baseline neurological function and clinic. Methods Resting-state fMRI were collected from 35 patients with recurrent ON and 50 normal controls who were matched in sex, age and education with patients. The amplitude of low-frequency fluctuation (ALFF) difference was investigated and compared between 2 groups. The correlation of brain regions with significantly different mALFF with duration, Paced Auditory Serial Addition Test (PASAT) and vision was further explored. Results Compared to normal controls, patients with recurrent ON showed significantly decreased mALFF in left cuneus/precuneus, left superior temporal gyrus, bilateral inferior temporal gyri, bilateral lingual gyri, right middle occipital gyrus (P < 0.01), and significantly increased mALFF in bilateral inferior frontal gyri and left medial frontal gyrus (P < 0.01). The positive correlation between duration and mALFF in left superior temporal gyrus (r = 0.403, P < 0.05) and right lingual gyrus (r = 0.472, P < 0.05) was observed in recurrent ON patients. Conclusions Resting-state fMRI can detect decreased neurological function in the temporal and occipital lobes which are involved in visual processing and increased neurological function in the frontal lobe which is involved in default mode network (DMN) in recurrent ON. It will provide evidence for evaluating neurological function and predicting the prognosis of ON in the early stage.
Key words:
Optic neuritis,
Recurrence,
Magnetic resonance imaging
姚新宇, 段云云, 刘亚欧, 任卓琼, 黄靖, 孙峥, 毛贝, 吴云清, 张晓君, 李坤成. 复发性视神经炎静息态低频振幅功能磁共振成像研究[J]. 中国现代神经疾病杂志, 2016, 16(6): 344-348.
YAO Xin-yu, DUAN Yun-yun, LIU Ya-ou, REN Zhuo-qiong, HUANG Jing, SUN Zheng, MAO Bei, WU Yun-qing, ZHANG Xiao-jun, LI Kun-cheng. Study on resting-state fMRI based on amplitude of low-frequency fluctuation in patients with recurrent optic neuritis[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2016, 16(6): 344-348.